Journal of Comparative Physiology B

, Volume 158, Issue 6, pp 697–702 | Cite as

Interaction of harderian glands, illumination, and temperature on thyroid hormones in golden hamsters

  • R. A. Hoffman
  • L. B. Johnson
  • M. K. Vaughan
  • R. J. Reiter


In this study, Harderianectomy (Hdx) has been shown to differentially modify circulating levels of the thyroid hormones, T4 and T3, in male and female golden hamsters exposed to low photic intensities or to moderately low temperatures.

Specifically, low photic intensities depress circulating levels of T4 in both control and Harderianectomized (Hdx) male and female hamsters. In addition, T3 is decreased in both control and Hdx males but not in females, as a consequence of reduced levels of illumination. Moderately low temperatures (10°C) depress T4 in both control and Hdx males but not in females, while T3 is increased in both control male and female hamsters, and in Hdx males, but not Hdx females. The data suggest that the Harderian gland of males enhances the sensitivity of the TSH-thyroid axis to photic intensity and to lower temperatures, and further, that there is a considerable sexual difference in the role the Harderian glands may play in response to these two environmental factors.


Environmental Factor Sexual Difference Human Physiology Thyroid Hormone Golden Hamster 
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  1. Boas NF, Bates RA (1954) Role of the thyroid and anterior pituitary glands in the maintenance of the Harderian glands of the rat. Endocrinology 55:601–612Google Scholar
  2. Christiansen F, Dam H (1953) A sexual dimorphism of the Harderian glands in hamsters. Acta Physiol Scand 27:333–336Google Scholar
  3. Hoffman RA (1971) Influence of some endocrine organs, hormones, and blinding on the histology and porphyrins of the Harderian glands of golden hamsters. Am J Anat 132:463–477Google Scholar
  4. Hoffman RA, Corth R (1988) Photic environments: Physical and biological considerations. In: Reiter RJ (ed) Pineal research reviews 6:95–118, Alan R. Liss, New YorkGoogle Scholar
  5. Hoffman RA, Johnson LB, Corth R (1985) The effects of spectral power distribution and illuminance levels on key parameters in the male golden hamster and rat with preliminary observations on the effects of pinealectomy. J Pineal Res 2:217–238Google Scholar
  6. McMasters K, Hoffman RA (1984) Harderian glands: regulation of sexual ‘type’ by gonads and pineal gland. Biol Reprod 31:579–585Google Scholar
  7. Smelser GK (1943) Changes induced in Harderian glands of guinea pig by the injection of hypophyseal extracts. Anat Rec 86:41–57Google Scholar
  8. Vaughan MK, Powanda MC, Brainard GC, Johnson LY, Reiter RJ (1982) Effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, TSH and thyroid hormone levels in male and female Syrian hamsters. In: Reiter RJ (ed) The pineal and its hormones. Alan R. Liss, New YorkGoogle Scholar
  9. Vaughan GM, Vaughan MK, Seraile LG, Reiter RJ (1982) Thyroid hormones in male hamsters with activated pineals or melatonin treatment. In: Reiter RJ (ed) The pineal and its hormones. Alan R. Liss, New YorkGoogle Scholar
  10. Vaughan MK, Richardson RA, Johnson LY, Petterborg J, Powanda MX, Reiter RJ, Smith I (1983) Natural and synthetic analogues of melatonin and related compounds. II. Effects on plasma thyroid hormones and cholesterol levels in male Syrian hamsters. J Neurol Trans 56:279–291Google Scholar
  11. Vriend J (1985) Effects of melatonin and thyroxine replacement on thyrotropin, luteinizing hormone and prolactin in male hypothyroid hamsters. Endocrinology 117:1–6Google Scholar
  12. Vriend J, Reiter RJ (1977) Free thyroxine index in normal, melatonin-treated and blinded hamsters. Hormone Metab Res 9:231–234Google Scholar
  13. Vriend J, Wasserman RA (1986) Effects of afternoon injections of melatonin in hypothyroid male Syrian hamsters. Neuroendocrinology 42:498–503Google Scholar
  14. Vriend J, Richardson BA, Petterborg LJ, Vaughan GM, Reiter RJ (1984) Injections and/or implants of 6-chloromelatonin and mealatonin: effects on plasma thyroid hormones in male and female Syrian hamsters. Biomed Res 5:413–418Google Scholar
  15. Wetterberg A, Yuwiler A, Geller E (1970) Harderian gland: development and influence of early hormonal treatment on porphyrin content. Science 168:996–998Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • R. A. Hoffman
    • 1
  • L. B. Johnson
    • 2
  • M. K. Vaughan
    • 3
  • R. J. Reiter
    • 3
  1. 1.Department of BiologyColgate UniversityHamiltonUSA
  2. 2.Natural Resources Research InstituteUniversity of MinnesotaDuluthUSA
  3. 3.Department of Cellular and Structural BiologyUniversity of Texas Medical CenterSan AntonioUSA

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