Acta Neuropathologica

, Volume 74, Issue 2, pp 142–150 | Cite as

Epithelial properties of pleomorphic xanthoastrocytomas determined in ultrastructural and immunohistochemical studies

  • T. Iwaki
  • M. Fukui
  • A. Kondo
  • T. Matsushima
  • I. Takeshita
Regular Papers


Three cases of pleomorphic xanthoastrocytoma (PXA), one of which showed anaplastic evolution, are described. In all three the PXA tumors were well circumscribed and could be totally removed. Light-microscopically, pleomorphic tumor cells clustered gregariously and often formed alveolar structures. Electron microscopy revealed various epithelial properties, such as junctions and interdigitations between apposing tumor cells, and prominent basal laminae surrounding tumor nests. The circumscribed growth of PXA, as contrasted with an infiltrative growth of usual astrocytoma, can be attributed to the cellular cohesion based on the epithelial properties of the tumor cells. In the third patient, tumor recurred 6 months postoperatively. Although the recurrent tumor retained the alveolar structures, pleomorphism and various degenerative features of the tumor cells diminished with advance in the proliferative activities.

Key words

Pleomorphic xanthoastrocytoma Epithelial properties Circumscribed growth Electron microscopy Immunohistochemistry 


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  1. 1.
    Banerjee SD, Cohn RH, Bernfield MR (1977) Basal lamina of embryonic salivary epithelia. Production by the epithelium and role in maintaining lobular morphology. J Cell Biol 73:445–463Google Scholar
  2. 2.
    Bukeo T, Nakamura S, Nishimoto A, Tabuchi K (1985) Pleomorphic xanthoastrocytoma (Kepes): a case report (in Japanese). Neurol Surg 13:773–777Google Scholar
  3. 3.
    Dekker A, Krause JR (1973) Hyaline globules in human neoplasms. Arch Pathol 95:178–181Google Scholar
  4. 4.
    Foidart JM, Bere EW, Yaar M (1980) Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein. Lab Invest 42:336–342Google Scholar
  5. 5.
    Gomez JG, Garcia JH, Cohon LE (1985) A variant of cerebral glioma called pleomorphic xanthoastrocytoma: case report. Neurosurgery 16:703–706Google Scholar
  6. 6.
    Grant JW, Gallagher PJ (1986) Pleomorphic xanthoastrocytoma—Immunohistochemical methods for differentiation from fibrous histocytomas with similar morphology. Am J Surg Pathol 10:336–341Google Scholar
  7. 7.
    Jones MC, Drut R, Raglia G (1983) Pleomorphic xanthoastrocytoma: a report of two cases. Pediatr Pathol 1:459–467Google Scholar
  8. 8.
    Kepes JJ, Rubinstein LJ, Eng LF (1979) Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favorable prognosis. A study of 12 cases. Cancer 44:1839–1852Google Scholar
  9. 9.
    Kepes JJ, Fulling KH, Garcia JH (1982) The clinical significance of “adenoid” formations of neoplastic astrocytes, imitating metastatic carcinoma, in gliosarcomas. A review of five cases. Clin Neuropathol 1:139–150Google Scholar
  10. 10.
    Kepes JJ, Sher J, Oliver MG (1985) Light and electron microscopic study of “adenoid” components in gliomas. Fibroblastic activity of neoplastic astrocytes. J Neuropathol Exp Neurol 44:359Google Scholar
  11. 11.
    Kuhajda FP, Mendelsohn G, Taxy JB, Long DM (1981) Pleomorphic xanthoastrocytoma: report of a case with light and electron microscopy. Ultrastruct Pathol 2:25–32Google Scholar
  12. 12.
    Kuramitsu M, Sawa H, Takeshita I, Iwaki T, Kato K (1981) Neuronspecific γ-enolase derived from human glioma. Neurochem Pathol 4:89–105Google Scholar
  13. 13.
    Kusaka H, Hirano A, Bornstein MB, Raine CS (1985) Basal lamina formation by astrocytes in organotypic cultures of mouse spinal cord tissue. J Neuropathol Exp Neurol 44:295–303Google Scholar
  14. 14.
    Lyser KM (1972) The differentiation of glial cells and glia limitans in organ cultures of chick spinal cord. In Vitro 8:77–84Google Scholar
  15. 15.
    Maleki M, Robitaille Y, Bertrand G (1983) Atypical xanthoastrocytoma presenting as a meningioma. Surg Neurol 20:235–238Google Scholar
  16. 16.
    Mannoji H, Takeshita I, Fukui M, Ohta M, Kitamura K (1981) Glial fibrillary acidic protein in medulloblastoma. Acta Neuropathol (Berl) 55:63–69Google Scholar
  17. 17.
    Nabeshima S, Reese TS, Landis DMD, Brightman MW (1975) Junctions in the meninges and marginal glia. J Comp Neurol 164:127–170Google Scholar
  18. 18.
    Palma L, Maleci A, Lorenzo ND, Lauro GM (1985) Pleomorphic xanthoastrocytoma with 18-year survival. Case report. J Neursurg 63:808–810Google Scholar
  19. 19.
    Peters A, Palay SL, Webser H deF (1976) The fine structure of the nervous system: the neurons and supporting cells. Saunders, Philadelphia, pp 233–248Google Scholar
  20. 20.
    Rubinstein LJ (1972) Tumors of the central nervous system, 2nd series. AFIP, Washington, pp 33–34Google Scholar
  21. 21.
    Russell DS, Rubinstein LJ (1977) Pathology of tumors of the nervous system. 4th edn. Arnold, London, pp 183–188Google Scholar
  22. 22.
    Sakai H, Kawano N, Okada K, Tanabe T, Yada K, Yagishita S (1981) A case of pleomorphic xanthoastrocytoma (Kepes) (in Japanese). Neurol Surg 9:1519–1524Google Scholar
  23. 23.
    Sawa H, Takeshita I, Kuramitsu M, Mannoji H, Machi T, Fukui M, Kitamura K (1987) Neuronal and glial proteins in medulloblastomas. Immunohistochemical study. Anticancer Res 6:905–910Google Scholar
  24. 24.
    Schiffer D, Giordana MT, Mauro A, Migheli A (1984) GFAP, F VIII/RAg, laminin, and fibronectin in gliosarcomas: an immunohistochemical study. Acta Neuropathol (Berl) 63:108–116Google Scholar
  25. 25.
    Strøm EH, Skullerud K (1983) Pleomorphic xanthoastrocytoma: report of 5 cases. Clin Neuropathol 2:188–191Google Scholar
  26. 26.
    Weldon-Linne CM, Victor TA, Groothuis DR, Vick NA (1983) Pleomorphic xanthoastrocytoma. Ultrastructural and immunohistochemical study of a case with a rapidly fatal outcome following surgery. Cancer 52:2055–2063Google Scholar
  27. 27.
    Yamashita M, Takeshita I, Mannoji H, Egami H, Ohta M, Kitamura K (1981) Establishment and maintenance of a human glioma transplanted serially to hereditary asplenicathymic (Lasat) mice. Exp Cell Biol 49:41–53Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • T. Iwaki
    • 1
  • M. Fukui
    • 2
  • A. Kondo
    • 1
  • T. Matsushima
    • 2
  • I. Takeshita
    • 2
  1. 1.Department of Neuropathology, Neurological Institute, Faculty of MedicineKyushu University 60FukuokaJapan
  2. 2.Department of Neurosurgery, Neurological Institute, Faculty of MedicineKyushu University 60FukuokaJapan

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