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Nuclear inclusion in oculopharyngeal dystrophy


The ultrastructural examination of skeletal muscle biopsies of three typical cases of autosomal dominant inherited oculopharyngeal muscular dystrophy showed collections of tubular filaments (8.5 nm in diameter) within muscle fibre nuclei. These filaments appear to be a characteristic morphological feature of oculopharyngeal dystrophy.

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Tomé, F.M.S., Fardeau, M. Nuclear inclusion in oculopharyngeal dystrophy. Acta Neuropathol 49, 85–87 (1980).

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Key words

  • Oculopharyngeal muscular dystrophy
  • Muscle biopsy
  • Nuclear inclusions
  • Electron microscopy