Acta Neuropathologica

, Volume 57, Issue 4, pp 282–286 | Cite as

Selective loss of small myelinated and unmyelinated fibers in Shy-Drager syndrome

  • H. Tohgi
  • M. Tabuchi
  • M. Tomonaga
  • N. Izumiyama
Original Works


The number and sizes of myelinated and unmyelinated fibers in biopsied sural nerves in cases with Shy-Drager syndrome were studied in comparison with cases with olivopontocerebellar degeneration not having autonomic dysfunction. In Shy-Drager syndrome, there was a tendency for both small myelinated and unmyelinated fiber densities to be reduced in comparison with cases with olivopontocerebellar degeneration. Unmyelinated fibers more than 0.5 μm in diameter were significantly reduced in Shy-Drager syndrome, a fact suggesting unmyelinated fiber degeneration. Multilamellated Schwann cell processes, isolated Schwann cell processes, and collagen pockets were more numerous and conspicuous in cases with Shy-Drager syndrome. It was concluded that unmyelinated fibers and small myelinated fibers in the peripheral nerves were involved selectively in Shy-Drager syndrome. The significance of the findings was discussed in terms of autonomic dysfunction observed clinically.

Key words

Shy-Drager syndrome Sural nerve Umyelinated fiber loss Small myelinated fiber loss Autonomic dysfunction 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • H. Tohgi
    • 1
  • M. Tabuchi
    • 1
  • M. Tomonaga
    • 1
  • N. Izumiyama
    • 2
  1. 1.Dept. of NeurologyTokyo Metropolitan Geriatric HospitalTokyoJapan
  2. 2.Dept. of Clinical PathologyTokyo Metropolitan Institute of GerontologyTokyoJapan

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