Acta Neuropathologica

, Volume 57, Issue 4, pp 263–269 | Cite as

Distal neuropathy in spontaneous diabetes mellitus in the dog

  • K. G. Braund
  • J. E. Steiss
Original Works


Peripheral nerves of three mature dogs with chronic spontaneous diabetes mellitus were examined using qualitative and quantitative techniques. The principal pathologic findings in single-teased fibers were remyelination and axonal regeneration. It is suggested that these changes which occurred in distal plantar nerves but not in more proximal tibial nerves result from a distal axonopathy. The dog may prove to be another useful spontaneous model of diabetic neuropathy.

Key words

Spontaneous diabetes Canine diabetic neuropathy Distal axonopathy Animal model 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • K. G. Braund
    • 1
  • J. E. Steiss
    • 2
  1. 1.Scott-Ritchey Research Program, School of Veterinary MedicineAuburn UniversityAuburnUSA
  2. 2.Dept. of Physiology, College of MedicineUniversity of SaskatchewanSaskatoonCanada

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