Acta Neuropathologica

, Volume 61, Issue 3–4, pp 313–315 | Cite as

Experimental phenylketonuria: Effect of phenylacetate intoxication on number of synapses in the cerebellar cortex of the rat

  • O. Robain
  • H. M. Wisniewski
  • Y. H. Loo
  • G. Y. Wen
Short Original Communications


In experimental phenylketonuria, induced in the rat by exposure to phenylacetate during the first 21 days of life, there was a significant reduction of boutons, a decrease of an average of 25% in the whole cerebellar molecular layer. Both the density of synaptic profiles per square unit and the number of synapses per unit volume were decreased in the phenylacetatetreated rat as compared to the age-matched control. Neuronal density was unaffected. Results are interpreted to show a deficit of synapses per neuron, probably due to a decrease in synaptic formation in phenylacetate-induced phenylketonuria. Undernutrition was eliminated as a contributing factor.

Key words

Synaptic density Phenylketonuria Phenylacetate neurotoxicity 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • O. Robain
    • 1
  • H. M. Wisniewski
    • 2
  • Y. H. Loo
    • 2
  • G. Y. Wen
    • 2
  1. 1.Hôpital Saint-Vincent-De-PaulParisFrance
  2. 2.New York State Institute for Basic Research in Developmental DisabilitiesStaten IslandUSA

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