Acta Neuropathologica

, Volume 40, Issue 3, pp 273–276 | Cite as

Multifocal leukoencephalopathy in adult leukemia: Histologic features and etiologic considerations

  • Julio H. Garcia
  • Uriel Sandbank
  • Philip Gutin
Short Original Communications


A number of structural alterations in brains of leukemic children have been attributed to intrathecal administration of methotrexate and radiation therapy. We report an instance of asymptomatic encephalopathy in an adult who received thio-TEPA (by subarachnoid injection) as treatment for leukemic meningitis. The lesions were microscopic, confined to cerebral white matter and included: vacuolation, myelin destruction, axonal swelling, gliosis, deposition of mineral salts and aggregates of large foamy cells. The etiology of this condition remains undetermined.

Key words

Leukemia CNS White-mater disease Chemotherapy Radiotherapy 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Julio H. Garcia
    • 1
  • Uriel Sandbank
    • 1
  • Philip Gutin
    • 1
  1. 1.Department of PathologyUniversity of Maryland, School of Medicine, Section of Neuro-Oncology, Baltimore Cancer Research Center, National Cancer InstituteBaltimoreUSA

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