Acta Neuropathologica

, Volume 25, Issue 4, pp 249–258 | Cite as

Biometrical and histochemical comparison between extra- and intra-fusal muscle fibres in denervated and re-innervated rat muscle

  • J. de Reuck
  • H. van der Eecken
  • H. Roels
Original Investigations


Biometrical and histochemical changes in extra- and intrafusal muscle fibres were determined in twenty adult rats during denervation and re-innervation. The right sciatic nerve was severed and at regular intervals the denervated gastrocnemius, soleus and peroneal muscles were examined and compared with the corresponding muscles of the non denervated limb.

Although the extra- and intra-fusal muscle fibres show the same histochemical changes, the atrophy of the intra-fusal muscle fibres is insignificant compared with the atrophy of the extra-fusal muscle fibres in the denervation phase. This could be explained by the small size of the intra-fusal fibres and the increased fluid resorption of the spindle.

In the re-innervation phase the same histochemical changes occur in both types of muscle fibres.

Key words

Denervation Atrophy Muscle Spindle Muscle Fibre Size Alkaline Phosphatase A.T.P.ase Cholinesterase Phosphorylase Succinate Dehydrogenase 


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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • J. de Reuck
    • 1
    • 2
  • H. van der Eecken
    • 1
    • 2
  • H. Roels
    • 1
    • 2
  1. 1.Department of Neurology and Department of PathologyUniversity of GhentBelgium
  2. 2.Department of NeurologyAcademisch ZiekenhuisGent(Belgium)

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