Acta Neuropathologica

, Volume 20, Issue 4, pp 278–287 | Cite as

Observations on cerebral and cerebellar microgyria

  • Guillermo A. de León
Original Investigations


The occurrence of cerebral and cerebellar microgyria in a case of intrauterine infection possibly due to Toxoplasma gondii is reported. A few aspects of two additional micropolygyric brains are briefly reviewed. The deep neuronal lamina in the 4-layered type of cerebral micropolygyria seems to be the equivalent of the normal isocortical infragranular stratum rather than an ectopic subcortical structure. The micropolygyric second layer seems to represent the supragranular and sometimes also the granular laminae. It is suggested that cerebellar microgyria is probably the result of a pathological process involving the external granular layer. Extensive subpial and extrapial gliosis as well as ectopic neurons and myelinated fibers in the meninges were a prominent feature in all three brains. In the main case peculiar multinucleated cells, probably neurons, were found in some areas of the cerebral cortex.

Key words

Cerebellar Microgyria Ectopic Neurons Gliosis, Subpial and Extrapial Malformation Micropolygyria Multinucleated Neurons Toxoplasmosis 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Guillermo A. de León
    • 1
    • 2
  1. 1.Department of NeuropathologyInstitute of PsychiatryLondon
  2. 2.neuropathology LaboratoryThe Johns Hopkins HospitalBaltimore

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