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Acta Neuropathologica

, Volume 20, Issue 4, pp 278–287 | Cite as

Observations on cerebral and cerebellar microgyria

  • Guillermo A. de León
Original Investigations

Summary

The occurrence of cerebral and cerebellar microgyria in a case of intrauterine infection possibly due to Toxoplasma gondii is reported. A few aspects of two additional micropolygyric brains are briefly reviewed. The deep neuronal lamina in the 4-layered type of cerebral micropolygyria seems to be the equivalent of the normal isocortical infragranular stratum rather than an ectopic subcortical structure. The micropolygyric second layer seems to represent the supragranular and sometimes also the granular laminae. It is suggested that cerebellar microgyria is probably the result of a pathological process involving the external granular layer. Extensive subpial and extrapial gliosis as well as ectopic neurons and myelinated fibers in the meninges were a prominent feature in all three brains. In the main case peculiar multinucleated cells, probably neurons, were found in some areas of the cerebral cortex.

Key words

Cerebellar Microgyria Ectopic Neurons Gliosis, Subpial and Extrapial Malformation Micropolygyria Multinucleated Neurons Toxoplasmosis 

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References

  1. Angevine, J. B., Sidman, R. L.: Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse. Nature (Lond.)192, 766–768 (1961).Google Scholar
  2. Berry, M., Eayrs, J. T.: Histogenesis of the cerebral cortex. Nature (Lond.)197, 984–985 (1963).Google Scholar
  3. —, Rogers, A. W.: The migration of neuroblasts in the developing cerebral cortex. J. Anat. (Lond.)99, 691–709 (1965).Google Scholar
  4. Bielschowsky, M.: Über die Oberflächengestaltung des Großhirnmantels bei Pachygyrie, Mikrogyrie und bei normaler Entwicklung. J. Psychol. Neurol. (Lpz.)30, 29–76 (1923/24).Google Scholar
  5. Crome, L.: Microgyria. J. Path. Bact.64, 479–495 (1952).Google Scholar
  6. — Pachygyria. J. Path. Bact.71, 335–352 (1956).Google Scholar
  7. — Stern, J.: The pathology of mental retardation, p. 113. London: J. & A. Churchill Ltd. 1967.Google Scholar
  8. Ebels, E. J.: The influence of age upon the effect of early postnatal x-irradiation on the development of the cerebellar cortex in rats. Acta neuropath. (Berl.)15, 298–307 (1970).Google Scholar
  9. Margolis, G., Kilham, L.: Virus induced cerebellar hypoplasia. Res. Publ. Ass. Res. nerv. ment. Dis.44, 113–145 (1968).Google Scholar
  10. Phemister, R. D., Shively, J. N., Young, S.: The effects of gamma irradiation on the postnatally developing canine cerebellar cortex. I. Effects of single sublethal exposure. J. Neuropath. exp. Neurol.28, 119–127 (1969a).Google Scholar
  11. ——— The effects of gamma irradiation on the postnatally developing canine cerebellar cortex. II. Sequential histogenesis on radiation induced changes. J. Neuropath. exp. Neurol.28, 128–138 (1969b).Google Scholar
  12. Poliakov, G. I., cited by P. Rakić and R. L. Sidman: J. Neuropath. exp. Neurol.27, 274 (1968).Google Scholar
  13. Rakié, P., Sidman, R. L.: Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans. J. comp. Neurol.139, 473–500 (1970).Google Scholar
  14. Tilney, F.: Behaviour in its relation to the development of the brain. Part II. Correlation between the development of the brain and behaviour in the albino rat from embryonic states to maturity. Bull. Neurol. Inst. N. Y.3, 252–258 (1933/34).Google Scholar
  15. Wyatt, J. A., Pollard, A. C.: Recurrent transient hyperglycaemia associated with collapse in identical twins. Proc. roy. Soc. Med.58, 690–692 (1965).Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Guillermo A. de León
    • 1
    • 2
  1. 1.Department of NeuropathologyInstitute of PsychiatryLondon
  2. 2.neuropathology LaboratoryThe Johns Hopkins HospitalBaltimore

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