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Observations on cerebral and cerebellar microgyria

Acta Neuropathologica volume 20, pages 278–287 (1972)Cite this article

Summary

The occurrence of cerebral and cerebellar microgyria in a case of intrauterine infection possibly due to Toxoplasma gondii is reported. A few aspects of two additional micropolygyric brains are briefly reviewed. The deep neuronal lamina in the 4-layered type of cerebral micropolygyria seems to be the equivalent of the normal isocortical infragranular stratum rather than an ectopic subcortical structure. The micropolygyric second layer seems to represent the supragranular and sometimes also the granular laminae. It is suggested that cerebellar microgyria is probably the result of a pathological process involving the external granular layer. Extensive subpial and extrapial gliosis as well as ectopic neurons and myelinated fibers in the meninges were a prominent feature in all three brains. In the main case peculiar multinucleated cells, probably neurons, were found in some areas of the cerebral cortex.

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Authors and Affiliations

  1. Department of Neuropathology, Institute of Psychiatry, London

    Guillermo A. de León

  2. neuropathology Laboratory, The Johns Hopkins Hospital, 304 Traylor Building, 21205, Baltimore, Maryland

    Guillermo A. de León

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  1. Guillermo A. de León
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de León, G.A. Observations on cerebral and cerebellar microgyria. Acta Neuropathol 20, 278–287 (1972). https://doi.org/10.1007/BF00691746

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  • DOI: https://doi.org/10.1007/BF00691746

Key words

  • Cerebellar Microgyria
  • Ectopic Neurons
  • Gliosis, Subpial and Extrapial
  • Malformation
  • Micropolygyria
  • Multinucleated Neurons
  • Toxoplasmosis