Acta Neuropathologica

, Volume 43, Issue 3, pp 259–262 | Cite as

Diffuse microglial proliferation after global ischemia in a patient with aplastic bone marrow

  • E. A. Neuwelt
  • J. H. Garcia
  • H. Mena
Short Original Communications


Abundant proliferation of cells having the histologic and tinctorial features of microglia, were seen in the brain of 34-year-old man who suffered cardiac arrest 10 days before death and whose bone marrow was nearly totally depleted of white-blood-cell precursors. It is suggested, that in adult human brains there are native microglial precursors which can take on a phagocytic function. Therefore, brain macrophages do not have to originate from circulating monocytes, as suggested by some animal studies.

Key words

Human brain inflammation Microglia Ischemia 


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  1. Blackwood, W.: Normal structure and general pathology of the nerve cell and neuroglia. In: Greenfield's Neuropathology (eds. W. Blackwood, J. A. N. Corsellis) p. 34. London: Arnold 1976Google Scholar
  2. Blinzinger, K., Kreutzberg, G. W.: Displacement of synaptic terminals from regenerating motor neurons by microglial cells. Z. Zellforsch,85, 145–157 (1968)Google Scholar
  3. Cammermeyer, J.: The life history of the microglial cell: A light microscopic study. In: Neurosciences Research, (Eds.) S. Ehrenpries, O. C. Solnitzky, Vol. 3, pp. 44–129. New York: Academic Press 1970Google Scholar
  4. Chui, E., Garcia, J. H., Albuquerque, E. X.: Microglial and neuronal recovery in spinal myelopathy induced by subarachnoid injection of 6-aminonicotinamide (in preparation)Google Scholar
  5. Del Rio-Hortega, P.: Microglia. In: Cytology and Cellular Pathology of the Nervous System, (Ed.) Penfield, W., pp. 483–534. Vol. II. New York: Hafner 1965 (orig. publ. in 1932)Google Scholar
  6. Del Rio-Hortega, P., Penfield, W.: Cerebral cicatrix: Reaction of neuroglia and microglia to brain wounds. J. Hopkins Hosp. Bull.41, 278–303 (1927)Google Scholar
  7. Feigin, I.: Presidential Address: Mesenchymal elements of the nervous system. The indigenous origin of brain macrophages in hypoxic states and in multiple sclerosis. J. Neuropathol. Exp. Neurol.28, 6–24 (1969)Google Scholar
  8. Fujita, S., Kitamura, T.: Origin of brain macrophages and the origin of microglia. Prog. Neuropath.3, 1–50 (1976)Google Scholar
  9. Garcia, J. H., Kamijyo, Y., Kalimo, H., Tanaka, J., Viloria, J. E., Trump, B. F.: Cerebral ischemia. The early structural changes and correlations of these with known metabolic and dynamic abnormalities. In: Cerebral Vascular Diseases (Princeton, New Jersey, January 9–11, 1974), (Eds.) T. P. Whisnant, B. Sandok, pp. 313–323. New York: Grune & Stratton 1975Google Scholar
  10. Kammlimo, H., Garcia, J. H., Kamijyo, Y., Tanaka, J., Vilòria, J. E., Valigorsky, J. M., Jones, R. T., Kim, K. M., Mergner, W. J., Pendergrass, R. E., Trump, B. F.: Cellular and subcellular alterations of human CNS. Studies utilizingin situ perfusion fixation at immediate autopsy. Arch. Pathol. Lab. Med.97, 352–359 (1974)Google Scholar
  11. Kirkpatrick, J. B.: Chromatoysis in the hypoglossal nucleus of the rat, an electron microscopic analysis. J. Comp. Neurol.132, 189–212 (1968)Google Scholar
  12. Konigsmark, B. S., Sidman, R. L.: Origin of brain macrophages in the mouse. J. Neuropathol. Exp. Neurol.22, 643–676 (1963)Google Scholar
  13. Neuwelt, E. A., Clark, K.: Clinical Aspects of Neuroimmunology. Baltimore: Williams and Wilkins 1978a (in press)Google Scholar
  14. Neuwelt, E. A., Clark, K.: Unique aspects of central nervous system immunology. Neurosurg. (1978b) (in press)Google Scholar
  15. Price, D. L.: The response of amphibian glial cells to axonal transection. J. Neuropathol. Exp. Neurol.31, 267–277 (1972)Google Scholar
  16. Russell, D. S.: Intravital staining of microglia with trypan blue. Am. J. Pathol.5, 451–457 (1929)Google Scholar
  17. Steegman, A. T.: The neuropathology of cardiac arrest. In: Pathology of the Nervous System, (Ed.) Minckler, J., Vol. I, pp. 1005–1027. New York: McGraw-Hill 1968Google Scholar
  18. Torvik, A.: Phagocytosis of nerve cells during retrograde degeneration. J. Neuropathol. Exp. Neurol.31, 132–146 (1972)Google Scholar
  19. Vaugh, J. E., Peters, A.: A third neuroglial cell type, an electron microscopic study. J. Comp. Neurol.133, 269–288 (1968)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • E. A. Neuwelt
    • 1
    • 2
  • J. H. Garcia
    • 1
    • 2
  • H. Mena
    • 1
    • 2
  1. 1.Baltimore Cancer Research CenterNCI, NIHBaltimoreUSA
  2. 2.Department of Pathology, Division of NeuropathologyUniversity of Maryland School of MedicineBaltimoreUSA

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