Acta Neuropathologica

, Volume 43, Issue 3, pp 259–262 | Cite as

Diffuse microglial proliferation after global ischemia in a patient with aplastic bone marrow

  • E. A. Neuwelt
  • J. H. Garcia
  • H. Mena
Short Original Communications
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Summary

Abundant proliferation of cells having the histologic and tinctorial features of microglia, were seen in the brain of 34-year-old man who suffered cardiac arrest 10 days before death and whose bone marrow was nearly totally depleted of white-blood-cell precursors. It is suggested, that in adult human brains there are native microglial precursors which can take on a phagocytic function. Therefore, brain macrophages do not have to originate from circulating monocytes, as suggested by some animal studies.

Key words

Human brain inflammation Microglia Ischemia 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • E. A. Neuwelt
    • 1
    • 2
  • J. H. Garcia
    • 1
    • 2
  • H. Mena
    • 1
    • 2
  1. 1.Baltimore Cancer Research CenterNCI, NIHBaltimoreUSA
  2. 2.Department of Pathology, Division of NeuropathologyUniversity of Maryland School of MedicineBaltimoreUSA

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