Acta Neuropathologica

, Volume 54, Issue 1, pp 83–87 | Cite as

Mitochondrial alterations in the spinal ganglion neurons in ageing rats

  • J. Vanneste
  • Ph. van den Bosch de Aguilar
Short Original Communication


An ultrastructural study of the mitochondria was performed in the 3-, 24-, and 32-month-old rats. Accumulation of “unusual” substances or structures was the most striking characteristic in senescent neuron mitochondria. Tubular or filamentous inclusions, modifications in matrix density, deposit of glycogen particles and electron-dense globules were observed. The various nature of these alterations and their different situation in the cristae or in the matrix, suggested that they could be the result of some specific xidative metabolism dysfunctions associated with ageing.

Key words

Ageing Spinal neurons Mitochondria 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • J. Vanneste
    • 1
  • Ph. van den Bosch de Aguilar
    • 1
  1. 1.Unité de Morphologie AnimaleUniversité Catholique de LouvainLouvain La NeuveBelgium

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