Acta Neuropathologica

, Volume 20, Issue 2, pp 139–149 | Cite as

Involvement of the perineurium in experimental allergic neuritis: Electron microscopic observations

Original Investigations


Electron microscopic observations on the perineurium in EAN are described. Extravasated serum protein was observed in the endoneurial space and also between the cellular laminae of the perineurium. A mechanism of macropinocytotic transport of protein across the perineurium is proposed. The observations are related to the known properties of the perineurium as a diffusion barrier and are interpreted as a mechanism by the perineurium to restore the composition of the endoneurial fluid.

Key words

Perineurium Experimental Allergic Neuritis Extravasated Protein Electron Microscopy 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • G. Allt
    • 1
  1. 1.Department of AnatomyUniversity College LondonLondonEngland

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