Summary
Electron microscopic observations on the perineurium in EAN are described. Extravasated serum protein was observed in the endoneurial space and also between the cellular laminae of the perineurium. A mechanism of macropinocytotic transport of protein across the perineurium is proposed. The observations are related to the known properties of the perineurium as a diffusion barrier and are interpreted as a mechanism by the perineurium to restore the composition of the endoneurial fluid.
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References
Allt, G.: The genesis of experimental allergic neuritis and encephalomyelitis: a critical evaluation. (In preparation).
—, Evans, E. M., Evans, D. H. L.: The vulnerability of immature rabbits to experimental allergic neuritis: a light and electron microscope study. Brain Res.29, 271–291 (1971).
Åström, K. E., Webster, H. de F., Arnason, B. G.: The initial lesion of experimental allergic neuritis. A phase and electron microscopic study. J. exp. Med.128, 469–495 (1968).
Ballin, R. H. M., Thomas, P. K.: Electron microscope observations on demyelination and remyelination in experimental allergic neuritis. Part. I Demyelination. J. neurol. Sci.8, 1–18 (1968).
——: Electron microscope observations on demyelination and remyelination in experimental allergic neuritis. Part 2. Remyelination. J. neurol. Sci.8, 225–237 (1969).
Böck, P., Hanak, H.: Die Verteilung exogener Peroxydase im Endoneuralraum. Histochemie25, 361–371 (1971).
Causey, G., Palmer, E.: The epineural sheath of a nerve as a barrier to the diffusion of phosphate ions. J. Anat. (Lond.)87, 30–36 (1953).
Cutler, R. W. P., Lorenzo, A. V., Barlow, C. F.: Brain vascular permeability to I125 gamma globulin and leukocytes in allergic encephalomyelitis. J. Neuropath. exp. Neurol.26, 558–571 (1967).
Denny-Brown, P.: Importance of neural fibroblasts in the regeneration of nerve. Arch. Neurol. Psychiat. (Chic.)55, 171–215 (1946).
Feng, T. P., Liu, Y. M.: The connective tissue sheath of the nerve as effective diffusion barrier. J. cell. comp. Physiol.34, 1–16 (1949).
Gamble, H. J., Eames, R. A.: An electron microscope study of the connective tissue of human peripheral nerve. J. Anat. (Lond.)98, 655–663 (1964).
Hall, J. I.: Studies on demyelinated peripheral nerves in guinea-pig with experimental allergic neuritis. A histological and electrophysiological study. Part I. Symptomatology and histological observations. Brain90, 297–312 (1967).
Hirano, A., Dembitzer, H. M., Becker, N. H., Levine, S.: Fine structural alterations of the blood-brain barrier in experimental allergic encephalomyelitis. J. Neuropath. exp. Neurol.29, 432–440 (1970).
Huxley, A. F., Stämpfli, R.: Effect of potassium and sodium on resting and action potentials of single myelinated nerve fibres. J. Physiol. (Lond.)112, 496–508 (1951).
Klemm, H.: Das Perineurium als Diffusionsbarriere gegenüber Peroxydase bei epi- und endoneuraler Applikation. Z. Zellforsch.108, 431–445 (1970).
Kurucz, J., Osgyáni, J.: Contributions to the pathomorphology of pulmonary innervation. Acta morph. Acad. Sci. hung.4, 227–232 (1954).
Kristensson, K.: Transport of fluorescent protein tracer in peripheral nerve. Acta neuropath. (Berl.)16, 293–300 (1970).
—, Olsson, Y.: The perineurium as a diffusion barrier to protein tracers. Differences between mature and immature animals. Acta neuropath. (Berl.)17, 127–138 (1971).
Lampert, P. W.: Mechanism of demyelination in experimental allergic neuritis. Electron microscope studies. Lab. Invest.20, 127–138 (1969).
—, Carpenter, S.: Electron microscopic studies on the vascular permeability and the mechanism of demyelination in experimental allergic encephalomyelitis. J. Neuropath. exp. Neurol.24, 11–24 (1965).
Levine, S., Hirano, A., Zimmerman, H. M.: Hyperacute allergic encephalomyelitis. Electron microscopic observations. Amer. J. Path.47, 209–221 (1965).
Lieberman, A. R.: The connective tissue elements of the mammalian nodose ganglion. An electron microscope study. Z. Zellforsch.89, 95–111 (1968).
Lorente de Nó, R.: The ineffectiveness of the connective tissue sheath of nerve as a diffusion barrier. J. cell. comp. Physiol.35, 195–240 (1950).
Mellick, R., Cavanagh, J. B.: Longitudinal movement of radioiodinated albumin within extravascular spaces of peripheral nerves following three systems of experimental trauma. J. Neurol. Neurosurg. Psychiat.30, 458–463 (1967).
Olsson, Y.: Studies on vascular permeability in peripheral nerves. 2. Distribution of circulating fluorescent serum albumin in rat sciatic nerve after local injection of 5-hydroxytryptamine, histamine and compound 48/80. Acta physiol. scand.69, Suppl. 284, 3–22 (1966).
—, Reese, T. S.: Permeability of vasa nervorum and perineurium in mouse sciatic nerve studied by fluorescence and electron microscopy. J. Neuropath. exp. Neurol.30, 105–119 (1971).
Schröder, J. M., Krücke, W.: Zur Feinstruktur der experimentell-allergischen Neuritis beim Kaninchen. Acta neuropath. (Berl.)14, 261–283 (1970).
Shantha, T. R., Bourne, G. H.: The perineural epithelium — a new concept, in The structure and function of nervous tissue, Vol. I, pp. 379–459. New York-London: Academic Press 1968.
Shanthaveerappa, T. R., Bourne, G. H.: The perineural epithelium, a metabolically active, continuous, protoplasmic barrier surrounding peripheral nerve fasiculi, J. Anat. (Lond.)96, 527–537 (1962).
——: The perineural epithelium: nature and significance. Nature (Lond.)199, 577–579 (1963).
——: The effects of transection of the nerve trunk on the perineural epithelium with special reference to its role in nerve degeneration and regeneration. Anat. Rec.150, 35–50 (1964).
Thomas, P. K.: The connective tissue of peripheral nerve: an electron microscope study. J. Anat. (Lond.)97, 35–44 (1963).
—, Jones, D. G.: The cellular response to nerve injury. 2. Regeneration of the perineurium after nerve section. J. Anat. (Lond.)101, 45–55 (1967).
Waggener, J. D., Bunn, S. M., Beggs, J.: The diffusion of ferritin within the peripheral nerve sheath: an electron microscopy study. J. Neuropath. exp. Neurol.24, 430–443 (1965).
Waksman, B. H., Adams, R. D.: Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvants. J. exp. Med.102, 213–236 (1955).
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Allt, G. Involvement of the perineurium in experimental allergic neuritis: Electron microscopic observations. Acta Neuropathol 20, 139–149 (1972). https://doi.org/10.1007/BF00691130
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DOI: https://doi.org/10.1007/BF00691130