Acta Neuropathologica

, Volume 44, Issue 3, pp 235–239 | Cite as

Choroid plexus papilloma: Light and electron microscopic study of three cases

  • J. J. Navas
  • H. Battifora
Original Works


Three cases of choroid plexus papilloma were studied by light and electron microscopy. All had the typical papillary pattern, and, in addition, two exhibited solid areas of tumor growth which predominated in one case.

PAS positive (diastase resistant) and argyrophilic cytoplasmic inclusions were present in all three tumors but were particularly abundant in the predominantly solid one. Ultrastructurally, the inclusions appeared as irregularly shaped structures containing lipid droplets, filamentous material and microtubules, and resembled the “silver bodies” of Biondi found in normal choroid plexus.

Along with other ultrastructural features of normal choroid plexus, these cytoplasmic inclusions may be helpful in the differential diagnosis of papillary tumors involving the ventricular system.

Key words

Choroid plexus papilloma Ultrastructure Cytoplasmic Inclusions Silver bodies 


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  1. Bargmann, W.: Histologia y Anatomia microscopica humana. 2nd ed., pp. 885–888. Barcelona: Editorial Labor S. A. 1964Google Scholar
  2. Bargmann, W., Katritsis, E.: Über die sog. Filamente und das Pigment im plexus choriodeus des Menschen. Z. Zellforsch.75, 366–370 (1966)Google Scholar
  3. Biondi, G.: Zur Histopathologie des menschlichen plexus choriodeus und des Ependyms. Arch. Psychiatr. Nervenkr.101, 666–728 (1934)Google Scholar
  4. Carter, L. P., Beggs, J., Waggener, J. D.: Ultrastructure of three choroid plexus papillomas, Cancer30, 1130–1136 (1972)Google Scholar
  5. Dohrmann, G. J., Bucy, P. C.: Human choroid plexus: a light and electron microscopic study. J. Neurosurg.33, 506–516 (1970)Google Scholar
  6. Dunn, J., Kernohan, J. W.: Histologic changes within the choroid plexus of the lateral ventricle: their relation to age. Proc. Mayo Clin.30, 607–615 (1956)Google Scholar
  7. Goebel, H. H., Cravioto, H.: Ultrastructure of human and experimental ependymomas, A comparative study. J. Neuropathol. Exp. Neurol.31, 54–71 (1972)Google Scholar
  8. Laurence, K. M.: The biology of choroid papilloma and carcinoma of the lateral ventricle. In: “Handbook of clinical neurology”, edited by P. J. Vinken and G. W. Bryn, volume 18, Tumors of the brain and skull, pp. 555–595. Amsterdam: North Holland 1975Google Scholar
  9. Lewis, P.: Carcinoma of the choroid plexus. Brain90, 177–186 (1967)Google Scholar
  10. Luse, S. A.: Electron microscopic studies of brain tumors. Neurology (Minneap.)10, 881–905 (1960)Google Scholar
  11. Maxwell, O. S., Pease, O. C.: The electron microscopy of the choroid plexus. J. Biophys. Biochem. Cytol.12, 467–476 (1962)Google Scholar
  12. Netzky, M. G., Shuangshoti, S.: The choroid plexus in health and disease. Charlottesville: University Press of Virginia 1975Google Scholar
  13. Oksche, A., Vaupel-von Harnack, M.: Electromikroskopische Studien über Altersveränderungen (Filamente) der plexus chorioidei des Menschen (Biopsiematerial). Z. Zellforsch.93, 1–29 (1969)Google Scholar
  14. Oksche, A., Kirschstein, H.: Enstehung und Ultrastruktur der Biondi-Körper in den plexus chorioidei des Menschen (Biopsiematerial). Z. Zellforsch.124, 320–341 (1972)Google Scholar
  15. Raimondi, A. J., Mullan, S., Evans, J. P.: Human brain tumors: an electron microscopic study. J. Neurosurg.19, 731–753 (1962)Google Scholar
  16. Rubinstein, L. J.: Tumors of the Central Nervous System. Atlas of Tumor Pathology, second series, fasc. 6, pp. 257–262. Washington, D. C.: Armed Forces Institute of Pathology 1972Google Scholar
  17. Shuangshoti, S., Netzky, M. G.: Human choroid plexus: morphologic and histochemical alterations with age. Am. J. Anat.128, 73–96 (1970)Google Scholar
  18. Shuangshoti, S., Tangschai, P., Netzky, M. G.: Primary adenocarcinoma of choroid plexus. Arch. Pathol. Lab. Med.91, 101–106 (1971)Google Scholar
  19. Tennyson, V. M., Pappas, G. O.: The fine structure of the choroid plexus. Adult and developmental stages. Prog. Brain. Res.29, 63–85 (1968)Google Scholar
  20. Vraa-Jensen, G.: Papilloma of choroid plexus with pulmonary metastases. Acta Psychiat.25, 299–306 (1950)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • J. J. Navas
    • 1
  • H. Battifora
    • 1
  1. 1.Department of PathologyNorthwestern University Medical SchoolChicagoUSA

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