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Psychopharmacology

, Volume 91, Issue 1, pp 101–103 | Cite as

Platelet [3H]imipramine binding in autism and schizophrenia

  • A. Weizman
  • N. Gonen
  • S. Tyano
  • G. A. Szekely
  • M. Rehavi
Original Investigations

Abstract

[3H]Imipramine binding to platelet membranes was evaluated in ten autistics, eight schizophrenics and seven normal controls. The schizophrenics and eight out of the ten autistics were maintained on chronic neuroleptic treatment. Diagnosis of autism and schizophrenia was established according to the DSM-III criteria. No significant difference in the maximal binding capacity of [3H]imipramine (Bmax) andKd values could be found among the three groups. It seems that the imipramine binding site is intact both in autism and schizophrenia.

Key words

Autism Schizophrenia Imipramine binding site Neuroleptics 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Weizman
    • 1
  • N. Gonen
    • 1
  • S. Tyano
    • 1
  • G. A. Szekely
    • 2
  • M. Rehavi
    • 3
  1. 1.Geha Psychiatric Hospital, Beilinson Medical Center, Petach Tiqva, and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  2. 2.Ness Ziona Government Psychiatric Hospital, Pediatric Department and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Department of Physiology and Pharmacology, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

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