Psychopharmacology

, Volume 91, Issue 1, pp 45–49 | Cite as

Haloperidol-induced emotional defecation: a possible model for neuroleptic anxiety syndrome

  • Kristanne H. Russell
  • Starr H. Hagenmeyer-Houser
  • Paul R. Sanberg
Original Investigations

Abstract

The neuroleptic haloperidol was found to produce increased defecation in laboratory rats when tested in well habituated environments. It is well known that haloperidol induces catalepsy through antagonism of striatal dopaminergic receptor mechanisms. When another cataleptic agent, morphine, was tested, no significant increases in defectation were detected. Another study focused on the possible role of peripheral dopamine receptor sites within the gastrointestinal tract on neuroleptic-induced defecation. When the peripheral dopamine receptor antagonist domperidone was tested, no significant differences in fecal elimination were recorded. Thus, it appeared that the cataleptic state per se, or the peripheral effects of haloperidol did not seem to be responsible for the increased defecation. Defection is often used as an index of emotionality. The fact that this measure increased following administration of a major tranquilizer suggested the need to study more directly the relationship of this phenomenon of defecation with the affective state of the animal. In a control study it was found that the antianxiety agent benzodiazepam did not by itself influence defecation. However, those animals which were pre-injected with diazepam followed by haloperidol did not show increased defecation. Thus under certain circumstances, normal rats given haloperidol show “emotional defecation” which seems to reflect increased anxiety. This finding may serve as a basis for the development of an animal model for some of the atypical side effects of major tranquilizers, such as akathisia, dysphoria, and neuroleptic anxiety syndrome.

Key words

Defecation Emotionality Anxiety Neuroleptics Haloperidol Domperidone Morphine Benzodiazepam 

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References

  1. Allain PP, Lechat P (1970) Action of psychotropic drugs on emotional defecation in mice. Therapie 25:566–662Google Scholar
  2. Bernardi MM, De Souza H, Neto J (1981) Effects of single and long-term haloperidol administration on open field behavior of rats. Psychopharmacology 73:171–175Google Scholar
  3. Bunsey MD, Sanberg PR (1986) The topography of the locomotor effects of haloperidol and dopamine. Behav Brain Res 19:147–152Google Scholar
  4. Caine ED, Polinsky RJ (1979) Haloperidol-induced dysphoria in patients with Tourette syndrome. Am J Psychiatry 136:1216–1217Google Scholar
  5. Costall B, Olley JE (1971) Cholinergic and neuroleptic induced catalepsy: modification by lesions in the caudate-putamen. Neuropharmacology 10:297–306Google Scholar
  6. Costall B, Naylor RJ (1976) Neuroleptic and non-neuroleptic catalepsy. Arzneimittelforsch 23:674–683Google Scholar
  7. Costall B, Naylor RJ, Olley JE (1972) Catalepsy and circling behavior after intracerebral injections of neuroleptic, cholinergic and anticholinergic agents into the caudate-putamen, globus pallidus and substantia nigra of the rat brain. Neuropharmacology 11:645–663Google Scholar
  8. Cox T, Tye N (1975) The effects of amphetamine, imipramine and ICI 58, 834 (vivalan), a potential antidepressant, on unconditioned behavior in rats. Psychopharmacologia 40:297–304Google Scholar
  9. De Ryck M, Teitelbaum P (1984) Morphine catalepsy as an adaptive reflex in rats. Behav Neurosci 98:243–261Google Scholar
  10. Freyhan FA (1980) Twenty years haloperidol: Clinical effectiveness and theoretical implications. Comp Psychiatry 21:251–257Google Scholar
  11. Gilman AG, Goodman LS, Rall TW, Murad F (1985) Goodman's and Gilman's: The pharmacological basis of therapeutics. MacMillan, New YorkGoogle Scholar
  12. Hall CS (1934) Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality. J Comp Psychol 18:385–403Google Scholar
  13. Hagenmeyer SH, Sanberg PR, Russell KH, Henault MA (1985) Haloperidol produces decreased activity and increased defecation in rats. Proceedings and Abstracts of the Eastern Psychological Association 56:58Google Scholar
  14. Holzbaur M, Sharman DF (1972) The distribution of catecholamines in vertebrates. In: Handbook of Experimental Pharmacology, vol. 33. Springer, Berlin Heidelberg New York, pp 110–185Google Scholar
  15. Kameyama T, Nabeshima T (1978) Effects of 1,3-dephenyl-5-(2 demthylaminopropionamide)-pyrazole (Difenanizole) on the conditioned avoidance. Neuropharmacology 17:249–256Google Scholar
  16. Kameyama TK, Suzuki M, Nabeshima T (1980) Effects of 5-hydroxytryptamine on defecation in open-field behavior in rats. Pharmacol Biochem Behav 12:875–882Google Scholar
  17. Koffer KB, Berney S, Hornykiewicz O (1978) The role of the corpus striatum in neuroleptic- and narcotic-induced catalepsy. Eur J Pharmacol 47:81–86Google Scholar
  18. Lal H (1975) Narcotic dependence, narcotic action and dopamine receptors. Life Sci 17:483–496Google Scholar
  19. Linet LS (1985) Tourette Syndrome, pimozide, and school phobia: The neuroleptic separation anxiety syndrome. Am J Psychiatry 145(5):613–615Google Scholar
  20. Mavrojannis M (1903) L'action cataleptic de la morphine chez les rats. Contribution a la theorie toxique de la catalepsie. CR Seanc Soc Biol 55:1092–1093Google Scholar
  21. Milo R (1980) Use of the peripheral dopamine antagonist, domperidone, in the management of gastrointestinal symptoms in patients with irritable bowel syndrome. Curr Med Res Opin 6:577–584Google Scholar
  22. Nakama M, Ochiai T, Kowa Y (1972) Effects of psychotropic drugs in emotional behavior. Exploratory behavior of naive rats in holed open-field. Jpn J Pharmacol 22:767–775Google Scholar
  23. Ormsbee HS (1984) Dopamine agonists/antagonists in the treatment of gastrointestinal diseases. In: Poste GP, Crooke ST (eds) Dopamine receptor agonists. Plenum, New York, pp 333–353Google Scholar
  24. Putten TV, May PRA, Marder SR, Wittman LA (1981) Subjective responses to antipsychotic drugs. Arch Gen Psychiatry 38:187–190Google Scholar
  25. Rebec GV, Gilman J, Alloway KD (1983) Cataleptic potency of the antipsychotic drugs is inversely correlated with neuronal activity in the amygadaloid complex of the rat. Pharmacol Biochem Behav 19:759–763Google Scholar
  26. Russell KH, Hagenmeyer-Houser SH, Sanberg PR (1986) Haloperidol produces increased defecation in rats in habituated environments. Bull Psychonom Soc (in press)Google Scholar
  27. Sanberg PR (1980) Haloperidol-induced catalepsy is mediated by postsynaptic dopamine receptors. Nature 284:472–473Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Kristanne H. Russell
    • 1
  • Starr H. Hagenmeyer-Houser
    • 1
  • Paul R. Sanberg
    • 1
  1. 1.Laboratory of Behavioral Neuroscience, Departments of Psychiatry, Psychology and PhysiologyUniversity of Cincinnati Medical CenterCincinnatiUSA

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