Advertisement

Acta Neuropathologica

, Volume 56, Issue 3, pp 233–237 | Cite as

Autonomic neurons of the sacral spinal cord in amyotrophic lateral sclerosis, anterior poliomyelitis and “neuronal intranuclear hyaline inclusion disease”: Distribution of sacral autonomic neurons

  • J. H. Sung
Original Works

Summary

Further evidence is presented that the Onuf's nucleus (or “colonne en torsade” of Laruelle) and the intermediolateral nucleus of the sacral cord share common selective vulnerability with the thoracolumbar intermediolateral nucleus in ALS, anterior poliomyelitis and “neuronal intranuclear hyaline inclusion disease”. Sparing of the sacral nuclei in the motor neuron diseases and neuronal loss of the nuclei in the multisystem atrophy are correlated well with normal and disturbed vesicorectal function. The clinicopathological evidence strongly supports the view that the Onuf's nucleus represents autonomic neurons much as the intermediolateral nucleus.

Key words

Autonomic neurons of sacral cord Selective vulnerability Degenerative disorders of neurons Vesicorectal function 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bannister R, Oppenheimer DR (1972) Degenerative diseases of the nervous system associated with autonomic failure. Brain 95:457–474Google Scholar
  2. Bok ST (1928) Das Rückenmark. In: Handbuch der mikroskopischen Anatomie des Menschen. Band 4, Das Nervensystem, Teil 1. Springer, Berlin, p 490Google Scholar
  3. Gagel O (1928) Zur Histologie und Topographie der vegetativen Zentren in Rückenmark. Z Anat Entwicklungsgesch 85:213–250Google Scholar
  4. Greving R (1978) Die zentralen Anteile des vegetativen Nerven-systems. In: Handbuch der mikroskopischen Anatomie des Menschen. Band 4, Das Nervensystem, Teil 1. Springer, Berlin, p 930Google Scholar
  5. Iwata M, Hirano A (1978) Sparing of the Onufrowicz nucleus in sacral anterior horn lesions. Ann Neurol 4:245–249Google Scholar
  6. Jacobsohn L (1908) Über die Kerne des menschlichen Rückenmarks. Abh d. Königl Preuss Akad d Wiss, Phys-math Classe (I)Google Scholar
  7. Jacobsohn-Lask L (1931) Über den medialen Sympathikuskern des menschlichen Rückenmarks. Z Ges Neurol Psychiat 134:649–656Google Scholar
  8. Johnson RH, Lee G, De J, Oppenheimer DR, Spalding JMK (1966) Autonomic failure with orthostatic hypotension due to intermediolateral column degeneration. A report of two cases with autopsies. Q J Med 35:276–292Google Scholar
  9. Laruelle L (1937) La structure de la moelle epinière en coupes longitudinales. Rev Neurol (Paris) 67:695–725Google Scholar
  10. Mannen T, Iwata M, Toyokura Y, Nagashima K (1977) Preservation of a certain motoneurone group of the sacral cord in amyotrophic lateral sclerosis: its clinical significance. J Neurol Neurosurg Psychiat 40:464–469Google Scholar
  11. Mannen T, Iwata M, Toyokura Y, Nagashima K (1979) Notes on a certain motoneuron group of the sacral cord in ALS and the Shy-Drager syndrome. In: Tsubaki T, Toyokura Y (eds) Proc Internat Symp Amyotrophic Lateral Sclerosis, Feb. 2–3, 1978. University of Tokyo Press, Tokyo, pp 201–207Google Scholar
  12. Massazza A (1923) La citoarchitettonica del midollo spinale umano. Arch Anat Histol Embryol (Strasb) 2:1–56Google Scholar
  13. Onuf (Onufrowicz) B (1900) On the arrangement and function of the cell groups of the sacral region of the spinal cord in man. Arch Neurol Psychopathol 3:387–412Google Scholar
  14. Pons-Tortella E, Roca de Viñals R, Rodriguez-Arias B (1951) La colonne fibrillaire de la moelle sacrée: sa morphologie, ses lésions dans la poliomyélite antérieure aigue, sa valeur fonctionelle. Rev Neurol (Paris) 85:165–177Google Scholar
  15. Rexed B (1954) A cytoarchitectonic atlas of the spinal cord in the cat. J Comp Neurol 100:297–351Google Scholar
  16. Sato M, Mizuno N, Konishi A (1978) Localization of motoneurons innervating perineal muscles: a HRP study in cat. Brain Res 140:149–154Google Scholar
  17. Sung JH (1979) Autonomic neurons affected by lipid storage in the spinal cord in Fabry's disease: Distribution of autonomic neurons in the sacral cord. J Neuropathol Exp Neurol 38:87–98Google Scholar
  18. Sung JH, Mastri AR (1980) Spinal autonomic neurons in Werdnig-Hoffmann disease, mannosidosis, and Hurler's syndrome: Distribution of autonomic neurons in the sacral spinal cord. J Neuropathol Exp Neurol 39:441–451Google Scholar
  19. Sung JH, Mastri AR, Segal E (1979) Pathology of Shy-Drager syndrome. J Neuropathol Exp Neurol 38:353–368Google Scholar
  20. Sung JH, Ramirez-Lassepas M, Mastri AR, Larkin SM (1980) An unusual degenerative disorder of neurons associated with a novel intranuclear hyaline inclusion (neuronal intranuclear hyaline inclusion disease): A clinicopathological study of a case. J Neuropathol Exp Neurol 39:107–130Google Scholar
  21. Yamamoto T, Satomi H, Ise H, Takatama H, Takahashi K (1978) Sacral spinal innervations of the rectal and vesical smooth muscles and the sphincteric striated muscles as demonstrated by the horseradish peroxidase method. Neurosci Lett 7:41–47Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • J. H. Sung
    • 1
  1. 1.Departmens of Laboratory Medicine and Pathology (Division of Neuropathology), and NeurologyUniversity of Minnesota Medical SchoolMinneapolisUSA

Personalised recommendations