Acta Neuropathologica

, Volume 41, Issue 3, pp 229–234 | Cite as

Electron microscopic structure of the alzheimer's neurofibrillary changes in case of atypical senile dementia

  • Hiroto Shibayama
  • Junzo Kitoh
Original Investigations


A man aged 70, showed early disorientation, memory defects, delusions and rages at 66, later mental deterioration with muteness and dysphagia. He died of cardiac failure. The postmortem examination revealed macroscopically and light microscopically the neuropathological findings of atypical senile dementia.

Moreover, it is the interesting characteristic in the presented case that there are electron microscopically two types of filaments making the neurofibrillary tangles. One showed the so-called “paired helical filaments”, which were observed in the cerebral cortex. The other showed parallel “straight filaments”. These “straight filaments” were found in the bilateral hippocampi.

Key words

Atypical senile dementia Electron microscopy Two types of filaments (neurofibrillary tangles) 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Hiroto Shibayama
    • 1
  • Junzo Kitoh
    • 2
  1. 1.Laboratory of NeuropathologyAichi Prefectural Shiroyama HospitalNagoyaJapan
  2. 2.Department of AnatomyNagoya University School of MedicineNagoyaJapan

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