Acta Neuropathologica

, Volume 41, Issue 3, pp 229–234 | Cite as

Electron microscopic structure of the alzheimer's neurofibrillary changes in case of atypical senile dementia

  • Hiroto Shibayama
  • Junzo Kitoh
Original Investigations

Summary

A man aged 70, showed early disorientation, memory defects, delusions and rages at 66, later mental deterioration with muteness and dysphagia. He died of cardiac failure. The postmortem examination revealed macroscopically and light microscopically the neuropathological findings of atypical senile dementia.

Moreover, it is the interesting characteristic in the presented case that there are electron microscopically two types of filaments making the neurofibrillary tangles. One showed the so-called “paired helical filaments”, which were observed in the cerebral cortex. The other showed parallel “straight filaments”. These “straight filaments” were found in the bilateral hippocampi.

Key words

Atypical senile dementia Electron microscopy Two types of filaments (neurofibrillary tangles) 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alzheimer, A.: Über eigenartige Krankheitsfälle des späteren Alters. Z. ges. Neurol. Psychiat.4, 356–385 (1911)Google Scholar
  2. Braunmühl, A. von, Leonhard, K.: Über ein Schwesterpaar mit Pickscher Krankheit. Z. ges. Neurol. Psychiat.150, 209–241 (1934)Google Scholar
  3. Brion, S., Mikol, J., Psimaras, A.: Recent findings in Pick's disease. In: Progress in neuropathology (ed. H. M. Zimmermann), pp. 421–452. New York: Grune and Stratton 1973Google Scholar
  4. Burger, P. C., Vogel, F. S.: The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. Am. J. Pathol.73, 457–476 (1973)Google Scholar
  5. Corsellis, J. A. N.: Subacute sclerosing leuco-encephalitis: a clinical and pathological report of two cases. Brit. J. Psychiat97, 570–583 (1951)Google Scholar
  6. Coulter, H. D.: Rapid and improved methods for embedding biological tissues in epon 812 and araldite 502. J. Ultrastruct. Res.20, 346–355 (1969)Google Scholar
  7. Crapper, D. R., Krishnan, S. S., Dalton, A. J.: Brain aluminium distribution in Alzheimer's disease and experimental neurofibrillary degeneration. Science180, 511–513 (1973)Google Scholar
  8. Hallervorden, J.: Zur Pathogenese des postencephalitischen Parkinsonismus. Klin. Wschr.12, 692–695 (1933)Google Scholar
  9. Hirano, A., Malamud, N., Kurland, L. T.: Parkinsonism-dementia complex, an endemic disease on the island of Guam. Brain84, 662–679 (1961)Google Scholar
  10. Hirano, A., Zimmermann, H. M.: Alzheimer's neurofibrillary changes. Arch. Neurol.7, 73–88 (1962)Google Scholar
  11. Hirano, A., Dembitzer, H. M., Kurland, L. T., Zimmermann, H. M.: The fine structure of some intraganglionic alterations. J. Neuropath. Exp. Neurol.27, 167–182 (1968)Google Scholar
  12. Hirano, A., Ghatak, N. R., Johnson, A. B., Partnow, M. J., Gomori, A. J.: Argentophilic plaques in Creutzfeldt-Jacob disease. Arch. Neurol.26, 530–542 (1972)Google Scholar
  13. Inose, T.: Die Histopathologie des senilen Gehirns. Psychiat. Neurol. jap. (Japanese)57, 63–96 (1955)Google Scholar
  14. Jellinger, K.: Neuroaxonal dystrophy: Its natural history and related disorders. In: Progress in Neuropathology (ed. H. M. Zimmermann), pp. 129–180. New York: Grune and Stratton 1973Google Scholar
  15. Jervis, G. A.: Early senile dementia in mongoloid idiocy. Amer. J. Psychiat.105, 102–106 (1948)Google Scholar
  16. Kidd, M.: Paired helical filaments in electron microscopy of Alzheimer's disease. Nature197, 192–193 (1963)Google Scholar
  17. Kidd, M.: Alzheimer's disease—an electron microscopical study. Brain87, 307–327 (1964)Google Scholar
  18. Klatzo, I., Wisniewski, H., Streicher, E.: Experimental production of neurofibrillary degeneration. J. Neuropath. Exp. Neurol.24, 187–199 (1965)Google Scholar
  19. Malamud, N., Haymaker, W., Pinkerton, H.: Inclusion encephalitis with a clinicopathologic report of three cases. Am. J. Path.26, 133–153 (1950)Google Scholar
  20. Matsuyama, H., Namiki, H., Watanabe, I.: Senile changes in the brain in the Japanese. Incidence of Alzheimer's neurofibrillary change and senile plaques. In: Proc. 5th Internat. Congr. Neuropath. Series No. 100. pp. 979–980 (eds. F. Luthy and A. Bischoff). Amsterdam: Excerpta Medica 1966Google Scholar
  21. Millonig, G.: Further observations on a phosphate buffer for osmium solutions. In: Electron microscopy (ed. S. S. Breese, Jr.), Vol. 2. New York-London: Academic Press 1962Google Scholar
  22. Mori, H., Nakamura, H., Wakutani, K.: Experimental neurofibrillary change induced by alminum lactate. Advanc. Neurol. Sci. (Japanese)13, 279–290 (1969)Google Scholar
  23. Nikaido, T., Austin, J., Rinehart, R., Trueb, L., Hätchinson, J., Stukenbrok, H., Miles, B.: Studies in ageing of the brain. I. Isolation and preliminary characterization of Alzheimer plaques and cores. Arch. Neurol.25, 198–211 (1971)Google Scholar
  24. Nikowitz, W. J., Mandybur, T. I.: Neurofibrillary changes following childhood lead encephalopathy. J. Neuropath. Exp. Neurol.34, 445–455 (1975)Google Scholar
  25. Ogäta, J., Badzilovich, G. N., Cravioto, H.: A study of rod-like structures (Hirano bodies) in 240 normal and pathological brains. Acta neuropath. (Berl.)21, 61–67 (1972)Google Scholar
  26. Ohara, P. T.: Electron microscopical study of the brain in Down's syndrome. Brain95, 681–684 (1972)Google Scholar
  27. Reynoulds, E. S.: The use of lead citrate at high pH as an electron microscopy. J. Cell Biol.17, 208–211 (1963)Google Scholar
  28. Rewcastle, N. B., Ball, M. J.: Electron microscopic structure of the “Inclusion bodies” in Pick's disease. Neurology18, 1205–1213 (1968)Google Scholar
  29. Rewcastle, N. B.: The 15 nm filament neurofibrillary tangle. Neuropath. Appl. Neurobiol2 (6), 490 (1976)Google Scholar
  30. Schochet, S. S., Lampert, P. W., Earle, K. M.: Neuronal changes induced by intrathecal vincristine sulfate. J. Neuropath. Exp. Neurol.27, 645–658 (1968)Google Scholar
  31. Schochet, S. S., Lampert, P. W., Lindenberg, R.: Fine structure of the Pick and Hirano bodies in a case of Pick's disease. Acta neuropath. (Berl.)11, 330–337 (1968)Google Scholar
  32. Schochet, S. S., Hardman, J. M., Ladewig, P. P., Earle, K. M.: Intraneuronal conglomerates in sporadic motor neuron disease. Arch. Neurol.20, 548–553 (1969)Google Scholar
  33. Schochet, S. S., Earle, K. M.: Pick's disease with compound intraneuronal inclusion bodies. Acta neuropath. (Berl.)15, 293–297 (1970)Google Scholar
  34. Shelanski, M. L., Wisniewski, H.: Neurofibrillary degeneration induced by vincristine therapy. Arch. Neurol.20, 199–206 (1969)Google Scholar
  35. Steele, J. C., Richardson, J. C., Olszewski, J.: Progressive supra-nuclear palsy. Arch. Neurol.10, 333–359 (1964)Google Scholar
  36. Tellez-Nagel, I., Wisniewski, H. M.: Ultrastructure of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome. Arch. Neurol.29, 324–327 (1973)Google Scholar
  37. Terry, R. D.: The fine structure of neurofibrillary tangles in Alzheimer's disease. J. Neuropath. Exp. Neurol.22, 629–642 (1963)Google Scholar
  38. Terry, R. D., Pena, C.: Experimental production of neurofibrillary degeneration. J. Neuropath. Exp. Neurol.24, 200–216 (1965)Google Scholar
  39. Terry, R. D.: Neuronal fibrous protein in human pathology, J. Neuropath. Exp. Neurol.30, 8–19 (1971)Google Scholar
  40. Towfighi, J.: Early Pick's disease. Acta neuropath. (Berl.)21, 224–231 (1972)Google Scholar
  41. Wisniewski, H., Terry, R. D.: Experimental colchicine encephalopathy. I. Induction of neurofibrillary degeneration. Lab. Invest.17, 577–587 (1967)Google Scholar
  42. Wisniewski, H., Johnson, A. B., Raine, C. S., Kay, W. J., Terry, R. D.: Senile plaques and cerebral amyloidosis in aged dogs. Lab. Invest.23, 287–296 (1970)Google Scholar
  43. Wisniewski, H., Terry, R. D., Hirano, A.: Neurofibrillary pathology. J. Neuropath. Exp. Neurol.29, 163–176 (1970)Google Scholar
  44. Wisniewski, H., Coblentz, J. M., Terry, R. D.: Pick's disease. A clinical and ultrastructural study. Arch. Neurol.26, 97–108 (1972)Google Scholar
  45. Wisniewski, H. M., Terry, R. D.: Reexamination of the pathogenesis of the senile plaque. In: Progress in neuropathology, Vol. II, pp. 1–26 (ed. Zimmermann). New York-London: Grune and Stratton 1973Google Scholar
  46. Wisniewski, H. M., Narang, H. K., Terry, R. D.: Neurofibrillary tangles of paired helical filaments. J. Neurol. Sci.27, 173–181 (1976)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Hiroto Shibayama
    • 1
  • Junzo Kitoh
    • 2
  1. 1.Laboratory of NeuropathologyAichi Prefectural Shiroyama HospitalNagoyaJapan
  2. 2.Department of AnatomyNagoya University School of MedicineNagoyaJapan

Personalised recommendations