Acta Neuropathologica

, Volume 68, Issue 3, pp 224–229 | Cite as

Retinal ultrastructure of neuronal ceroid-lipofuscinosis in the Dalmatian dog

  • H. H. Goebel
  • E. Dahme
Original Works


Ultrastructural studies of the retinae in two NCL-affected Dalmatian dogs revealed ubiquitous accumulation of lipopigments in numerous cell types of the retina, the fine structure of which closely resembled that seen in NCL-affected English setters. Photoreceptors and other retinal cell types were largely intact. These findings show that the retinal involvement in NCL of our Dalmatian dogs is identical to that of NCL-affected English setters. It also shows that in canine NCL a severe retinopathy, regularly encountered in human childhood NCL, does not develop. Thus, the NCL of Dalmatian dogs —and English setters — represents a reliable model to study human NCL, but for human retinopathia pigmentosa perhaps only at its earliest stage.

Key words

Dalmatian dogs Lipopigments Retina Retinopathy Ultrastructure Ceroidlipofuscinosis 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • H. H. Goebel
    • 1
  • E. Dahme
    • 2
  1. 1.Division of NeuropathologyUniversity of MainzMainzFederal Republic of Germany
  2. 2.Dept. of Veterinary Pathology (General Pathology and Neuropathology)University of MunichMunichFederal Republic of Germany

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