Breast Cancer Research and Treatment

, Volume 36, Issue 1, pp 93–97 | Cite as

Prognostic significance of heat-shock protein-27 in node-positive breast carcinoma: an immunohistochemical study

  • Bernard Têtu
  • Jacques Brisson
  • Jacques Landry
  • Jacques Huot
Brief communication


Immunostaining for heat-shock protein-27 (HSP-27) was performed on formalin fixed-paraffin embedded sections of 890 node-positive breast carcinomas resected between 1980 and 1986. The follow-up ranged from 2.5 to 10.5 years. A polyclonal antibody (Hu27, dilution: 1/200) was used. A positive cytoplasmic staining was obtained in 383 cases (43%). No difference in distant metastasis-free survival (DMFS) or overall survival (OS) was noted between cases with positive or negative immunostaining. This study suggests that HSP-27 expression is not predictive of the outcome in node-positive breast cancer.

Key words

breast cancer heat-shock prognostic factors stress-related protein 


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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Bernard Têtu
    • 1
  • Jacques Brisson
    • 2
  • Jacques Landry
    • 1
  • Jacques Huot
    • 1
  1. 1.Department of Pathology and ‘Le Centre de Recherche en Cancérologie de l'Université Laval’L'Hôtel-Dieu de QuébecQuébecCanada
  2. 2.Groupe de Recherche en Épidémiologie de l'Université LavalHôpital du St-SacrementQuébecCanada

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