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Reduction of B16 melanoma metastases by oral administration of egg-white lysozyme

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Summary

The oral administration of hen egg-white lysozyme to mice bearing B16 melanoma significantly reduces the formation of spontaneous lung metastases and, when combined with surgical removal of the primary tumor, prolongs the survival of the treated hosts. The antimetastatic effect, comparable with that found in the Lewis lung carcinoma and MCa mammary carcinoma systems, is independent of the direct interaction of lysozyme with tumor cells and tends to indicate the suggested intervention of an indirect action mediated by the induction of host responses.

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Authors and Affiliations

  1. Institute of Pharmacology, Faculty of Pharmacy University of Trieste, Via A. Valerio 32, 34127, Trieste, Italy

    Gianni Sava

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  1. Gianni Sava
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Additional information

This work was done in cooperation with Fondazione C. e D. Callerio, Trieste, Italy, and was supported by grants from the Italian Ministry of Education (MPI, 40% and 60%)

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Sava, G. Reduction of B16 melanoma metastases by oral administration of egg-white lysozyme. Cancer Chemother. Pharmacol. 25, 221–222 (1989). https://doi.org/10.1007/BF00689588

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  • DOI: https://doi.org/10.1007/BF00689588

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