Acta Neuropathologica

, Volume 41, Issue 1, pp 27–31 | Cite as

Cerebral tumors induced by transplacental ENU: Study of the different tumoral stages, particularly of early proliferations

  • D. Schiffer
  • M. T. Giordana
  • S. Pezzotta
  • C. Lechner
  • P. Paoletti
Original Investigations


Experimental cerebral tumors have been induced by transplacental ENU. A systematic diachronic study of the brains has been performed starting from the 15th day of extrauterine life. The tumoral lesions firstly appear as “early stage proliferations” or oligodendroglial foci and develop as glial micro-and macrotumors or as isomorphic and polymorphic oligodendrogliomas respectively.

Neurinomas appear later than glial tumors.

The duration of the different lesions is sketched out. The usefulness of the model for chemotherapy studies is discussed.

Key words

Experimental CNS tumors Transplacental ENU Early stage Tumor development 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • D. Schiffer
    • 1
  • M. T. Giordana
    • 1
  • S. Pezzotta
    • 2
  • C. Lechner
    • 2
  • P. Paoletti
    • 2
  1. 1.II. Neurological ClinicUniversity of TurinTurinItaly
  2. 2.Neurosurgical ClinicUniversity of PaviaItaly

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