Acta Neuropathologica

, Volume 54, Issue 2, pp 149–152 | Cite as

Experimental allergic encephalomyelitis

Exsudate and cellular infiltrates in the spinal cord of lewis rats
  • H. P. Ackermann
  • J. Ulrich
  • Ph. U. Heitz
Short Original Communications


Classical acute allergic encephalomyelitis (EAE) was provoked in Lewis rats with bovine spinal cord (BWM) in complete Freund's adjuvant (CFA). An efficient immunohistologic technique (peroxidase-antiperoxidase (PAP)) was used to trace exsudates of fibrinogen and immunoglobulin as well as their coexistence with cellular infiltrates and clinical signs. Exsudation was restricted to the vessels exhibiting cellular infiltrates. The findings do not lend support to the assumption that exsudation of circulating factors is the initial local event in EAE. It also remains open, whether the exsudation of fibrinogen and gamma globulin are responsible for the clinical symptoms.

Key words

Experimental allergic encephalomyelitis Blood Brain barrier Fibrinogen 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cutler RWP, Lorenzo A, Barlow CW (1967) Brain vascular permeability to I125-gamma-globulin in leukocytes in allergic encephalomyelitis. J Neuropathol Exp Neurol 26:558–571Google Scholar
  2. Field EJ, Raine CS (1966) Experimental allergic encephalomyelitis. An electron-microscopic study. Am J Pathol 49:537–544Google Scholar
  3. Gonatas NK, Howard JC (1974) Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T cells. Science 186:839–841Google Scholar
  4. Gonatas NK, Gonatas JO, Stieber A, Lisak R, Suzuki K, Martenson RE (1974) The significance of circulating an cell bound antibodies in experimental allergic encephalomyelitis. Am J Pathol 1976:529–548Google Scholar
  5. Holländer H, Mehrain P (1965) Vergleichende licht-und fluorescenzmikroskopische Untersuchungen der experimentellen allergischen Encephalomyelitis des Meerschweinchens. Acta Neuropathol (Berl) 5:205–214Google Scholar
  6. Lampert P, Carpenter S (1965) Electron-microscopic studies on the vascular permeability and the mechanism of demyelination in experimental allergic encephalomyelitis. J Neuropathol Exp Neurol 24:11–24Google Scholar
  7. Leibowitz S, Kennedy L (1972) Cerebral vascular permeability and cellular infiltration in experimental allergic encephalomyelitis. Immunology 22:859–869Google Scholar
  8. Oldstone MBA, Dixon SJ (1968) Immunohistochemical study of allergic encephalomyelitis. Am J Pathol 52:251Google Scholar
  9. Paterson PY (1960) Transfer of allergic encephalomyelitis in rats by means of lymph node cells. J Exp Med 3:119Google Scholar
  10. Paterson PY, Drobisch DG, Ginsberg MM (1974) Experimental allergic encephalomyelitis in cyclophosmide-treated Lewis rats: clinical remissions and releases and effect of treatment on neurofibrin deposits. Clin Immunol Immunopathol 2:456–464Google Scholar
  11. Paterson PY (1976a) Experimental allergic encephalomyelitis: role of fibrin deposition in immunopathogenesis of inflammation in rats. Fed Proc 35:2428–2434Google Scholar
  12. Paterson PY (1976b) Experimental autoimmune (allergic) encephalomyelitis: induction, pathogenesis, and suppression. In: Mieser P, Müller-Eberhard HJ (eds), Textbook of immunopathology. Grune and Stratton, New York, pp 179–214Google Scholar
  13. Paterson PY, Day ED (1979) Neuroimmunologic disease: experimental and clinical aspects. Hosp Pract 49–58Google Scholar
  14. Sternberger LA (1979) Immunocytochemistry, 2nd edn, J. Wiley, New York Chistester Brisbane TorontoGoogle Scholar
  15. Traugott W, Stone S, Raine CS (1978) Experimental allergic encephalomyelitis: migration of early T cells from the circulation into the central nervous system. J Neurol Sci 36:55–61Google Scholar
  16. Waksman BH, Morrison LR (1951) Tuberculin type sensitivity to spinal cord antigen in rabbits with isoallergic encephalomyelitis. J Immunol 66:421–444Google Scholar
  17. Waksman BH, Adams RD (1962) A histologic study of the early lesion in experimental allergic encephalomyelitis in the guinea pig and rabbit. Am J Pathol 41:135–162Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • H. P. Ackermann
    • 1
  • J. Ulrich
    • 1
  • Ph. U. Heitz
    • 1
  1. 1.Neuropathology Division and Laboratory of Histochemistry of the Department of PathologyUniversity of BasleBasleSwitzerland

Personalised recommendations