Summary
A case of veno-occlusive disease and peliosis of the liver without coexisting liver malignancy 35 years after thorotrast administration is presented.
In the liver four main widely distributed lesions were found: Venoocclusive disease (VOD), peliosis, fibrosis and thorotrast deposits.
Whether the VOD and the peliotic lesions are pathogenetically related or totally independent cannot be determined in the present case. However, the VOD and the peliosis are possibly related to the protracted alpha-emitting effect of thorotrast deposited in the liver parenchyma.
Similar content being viewed by others
References
Alpert LJ (1976) Veno-occlusive disease of the liver associated with oral contraceptives: Case report and review of literature. Hum Pathol 6:709–718
Arnold GL, Kaplan MM (1979) Peliosis hepatis due to oxymetholone - A clinically benigh disorder. Am J Gastroenterol 71:213–216
Bagheri SA, Boyer JL (1974) Peliosis hepatis associated with androgenic-anabolic steroid therapy: A severe form of hepatic injury. Ann Int Med 81:610–618
Baserga R, Yokoo H, Henegar GC (1960) Thorotrast induced cancer in man. Cancer 13:1021–1031
Berk PD, Popper H, Krueger GRF, Decter J, Herzig G, Graw RG (1979) Veno-occlusive disease of the liver after allogenic bone marrow transplantation. Ann Int Med 90:158–164
Bras G, Jellife DB, Stuart KL (1954) Veno-occlusive disease of liver with non portal type of cirrhosis, occuring in Jamaica. Arch Pathol 57:285–300
Degott C, Rueff B, Kreis H, Duboust A, Potet F, Benhamou JP (1978) Peliosis hepatis in recipients of renal transplants. Gut 19:748–753
Faber M (1979) Twenty-eight years of continuous follow-up of patients injected with thorotrast for cerebral angiography. Environ Res 18:37–43
Fajardo LF, Colby TV (1980) Pathogenesis of veno-occlusive disease of the liver after chemotherapy of acute leukemia. Arch Pathol Lab Med 104:584–588
Griner PF, Elbadawi A, Packman CH (1976) Veno-occlusive disease of the liver after chemotherapy of acute leukemia. Ann Int Med 85:578–582
Groos G, Arnold OH, Brittinger G (1974) Peliosis hepatis after long-term administration of oxymetholone. Lancet 1:874
Hahn PF, Jackson MA, Goldie H (1951) Liver cirrhosis with ascites, induced in dogs by chronic massive hepatic irradiation with radioactive colloidal gold. Science 114:303–305
Kent G, Thompson JR (1961) Peliosis hepatis. Involvement of reticuloendothelial system. Arch Pathol 72:658–664
Looney WB (1960) An investigation of the late clinical findings following thorotrast (Thorium dioxide) administration. Am J Roentgenol 83:163–185
McGiven AR (1970) Peliosis hepatis: Case report and review of pathogenesis. J Pathol 101:283–285
Mori T, Maruyama T, Kato Y, Watanabe S (1979) Epidemiological follow-up study of Japanese thorotrast cases. Environ Res 18:44–54
Nadell J, Kosek J (1977) Peliosis hepatis. Twelve cases associated with oral androgen therapy. Arch Pathol Lab Med 101:405–410
Naeim F, Copper PH, Semion AA (1973) Peliosis hepatis: Possible etiologic role of anabolic steroids. Arch Pathol 95:284–285
Okuda K, Omata M, Itoh Y, Ikezaki H, Nakashima T (1981) Peliosis hepatis as a late and fatal complication of thorotrast liver disease. Report of five cases. Liver 1:110–122
Orandi M, Pirozynski WJ (1967) Peliosis hepatis. Can Med Ass J 96:1219–1220
Pliskin M (1975) Peliosis hepatis. Radiology 114:29–30
Schoenlank W (1916) Ein Fall von Peliosis hepatis. Virchows Arch [Pathol Anat] 222:358–364
Selinger M, Koff RS (1975) Thorotrast and the liver: A Reminder. Gastroenterology 68:799–803
Shulmann HM, McDonald GB, Matthews D, Doney KC, Kopecky KJ, Gauvreau JM, Thomas ED (1980) An analysis of hepatis veno-occlusive disease and centrilobular hepatic degeneration following bone marrow transplantation. Gastroenterology 79:1178–1191
Sherlock S (1981) Diseases of the liver and biliary system. (6th ed). Blackwell Scientific Publications, Oxford
Stuart KL, Bras G (1957) Veno-occlusive disease of the liver. Quart J Med 26:291–315
Taxy JB (1978) Peliosis: A morphologic curiosity becomes an iatrogenic problem. Hum Pathol 9:331–340
Viala JJ, Berger F, Guastalla JP, Vignal J, Chassard JL, Blanc M (1981) Peliose hepatique localisée apres cobaltothérapie épigastrique. Arch Anat Cytol Pathol 292:118–120
Visfeldt J, Poulsen H (1972) On the histopathology of liver and liver tumours in thoriumdioxide patients. Acta Pathol Microbiol Scand Sect A 80:97–108
Wegener K (1979) Systemic review of thorotrast data and facts: Animal experiments. Virchows Arch [Pathol Anat] 381:245–268
Weitz H, Gokel JM, Loeschke K, Possinger K, Eder M (1982) Veno-occlusive disease of the liver in patients receiving immunosuppressive therapy. Virchows Arch [Pathol Anat] 395:245–256
Winkler K, Poulsen H (1975) Liver disease with periportal sinusoidal dilatation. A possible complication to contraceptive steroids. Scan J Gastroenterol 10:699–704
Yanoff M, Rawson AJ (1964) Peliosis hepatis. An anatomic study with demonstration of two varieties. Arch Pathol 77:159–165
Zak FG (1959) Peliosis hepatis. Am J Pathol 26:1–15
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dejgaard, A., Krogsgaard, K. & Jacobsen, M. Veno-occlusive disease and peliosis of the liver after thorotrast administration. Vichows Archiv A Pathol Anat 403, 87–94 (1984). https://doi.org/10.1007/BF00689341
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00689341