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Cancer Chemotherapy and Pharmacology

, Volume 27, Issue 1, pp 76–78 | Cite as

Cerebellar toxicity during cytarabine therapy associated with renal insufficiency

  • Henrik Hasle
Short Communication Cytarabine, Cerebellar Toxicity, Renal Insufficiency

Summary

Acute cerebellar toxicity with ataxia and dysarthria is a well-known side effect during high-dose cytarabine therapy. Dose, age, previous neurological disorders, hepatic dysfunction, and renal insufficiency have been inconsistently reported as risk factors. The present paper presents a patient with renal insufficiency who developed severe cerebellar toxicity following treatment with a dose of cytarabine (8 g/m2 over 5 days) not generally expected to be associated with neurotoxicity. Together with a review of the literature, the present case gives evidence of renal insufficiency as a major risk factor in the development of cerebellar toxicity during cytarabine therapy. Reduced doses of cytarabine should be considered in patients with renal impairment.

Keywords

Cancer Research Neurological Disorder Renal Impairment Renal Insufficiency Cytarabine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Henrik Hasle
    • 1
  1. 1.Division of Haemtology, Department of Oncology and RadiotherapyUniversity Hospital of OdenseOdense CDenmark

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