Summary
The histological features of cerebellar microgyria are described in a 15 month old infant. The bizarre appearance of this malformation seems to be the result of two basic factors: secondary fusion between preformed folia, and deficient and disorderly formation of the internal granule cell layer. The findings support the view according to which cerebellar microgyria is probably due to a pathological process involving the external granule cell layer during a relatively late period of cerebellar development.
This is a preview of subscription content, log in via an institution to check access.
References
Ebels, E. J.: The influence of age upon the effect of early postnatal X-irradiation on the development of the cerebellar cortex in rats. Acta neuropath. (Berl.)15, 298–307 (1970)
Ebels, E. J., Peters, I., Thijs, A.: Studies on ectopic granule cells in the cerebellar cortex. III. An investigation into the restoration of the external granular layer after partial destruction. Acta neuropath. (Berl.)31, 103–107 (1975)
Fischer, D. S., Jonas, A. M.: Cerebellar hypoplasia resulting from cytosine arabinoside treatment in the neonatal hamster. (Abstract). Clin. Res.13, 540 (1965)
Friedman, H. M., Gilden, D. H., Roosa, R. A., Nathanson, N.: The effect of neonatal thymectomy on Tamiami virus-induced central nervous system disease. J. Neuropath. exp. Neurol.34, 159–166 (1975)
de León, G. A.: Observations on cerebral and cerebellar microgyria. Acta neuropath. (Berl.)20, 278–287 (1972)
Margolis, G., Kilham, L.: Cerebellar ontogenetic patterns: key to a virus code. In: The cerebellum in health and disease, (eds. W. S. Fields and W. D. Willis, Jr.), pp. 353 to 377. St. Louis: W. H. Green, Inc. 1970
Miale, I. L., Sidman, R. L.: An autoradiographic analysis of histogenesis in the mouse cerebellum. Exp. Neurol.4, 277–296 (1961)
Norman, R. M.: Cerebellar malformations. In: Greenfield's neuropathology, 2nd ed., (eds. W. Blackwood, W. H. McMenemey, A. Meyer, R. M. Norman, and D. S. Russel), pp. 363–365. Baltimore: Williams and Wilkins Co. 1963
Ramón y Cajal, S.: Histologie du systèse nerveux de l'homme et des vertébrés. 2 vol. Madrid: C.S.I.C. 1911
Author information
Authors and Affiliations
Additional information
Supported in part by Department of Health, Education and Welfare Training Grant No. 1-T01-NS10072-0182, N.S.R.A.
Rights and permissions
About this article
Cite this article
de León, G.A., Grover, W.D. & Mestre, G.M. Cerebellar microgyria. Acta Neuropathol 35, 81–85 (1976). https://doi.org/10.1007/BF00688946
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688946