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Acta Neuropathologica

, Volume 57, Issue 1, pp 75–79 | Cite as

Senile dementia of Alzheimer type: Astroglial reaction to extracellular neurofibrillary tangles in the hippocampus

An immunocytochemical and electron-microscopic study
  • A. Probst
  • J. Ulrich
  • Ph. U. Heitz
Short Original Communication

Summary

Two types of Alzheimer neurofibrillary tangles may be found in the hippocampus in senile dementia of the Alzheimer type. Besides classical flameshaped intraneuronal tangles, there are less compact tangles representing extracellular remnants of destroyed neurons with neurofibrillary change. Strong immunoreactivity for glial fibrillary acidic protein (GFA) was found in the second type of tangles, which was due to penetration of fine processes of fibrous astrocytes into bundles of paired helical filaments (PHF). PHF appear to be a strong stimulus for astrocytic reaction when they are not segregated from the neuropil by the neuronal cell membrane.

Key words

Senile dementia of Alzheimer type Neurofibrillary tangles Fibrous astrocytes Immunocytochemistry 

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References

  1. Alzheimer A (1907a) Über eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiat 64:146–148Google Scholar
  2. Alzheimer A (1907b) Über eine eigenartige Erkrankung der Hirnrinde. Zentralbl Ges Neurol Psychiat 18:177–179Google Scholar
  3. Baskin DG, Erlandsen SL, Parsons JA (1979a) Immunocytochemistry with osmium-fixed tissue. I. Light-microscopic localization of growth hormone and prolactin with the unlabeled antibody-enzyme method. J Histochem Cytochem 27:867–872Google Scholar
  4. Baskin DG, Erlandsen SL, Parsons JA (1979b) Influence of hydrogen peroxide of alcoholic sodium hydroxide on the immunocytochemical detection of growth hormone and prolactine after osmium fixation. J Histochem Cytochem 27:1290–1292Google Scholar
  5. Eng LF (1980) The glial fibrillary acidic (GFA) protein. In: Bradshow R, Schneider D (eds) Proteins of the nervous system, 2nd ed. Raven Press, New York, pp 85–117Google Scholar
  6. Glenner GG (1980) Amyloid deposits and amyloidosis: The β-fibrillosis. New Engl J Med 302:1283–1292, 1333–1343Google Scholar
  7. Grube D (1980) Immunoreactivities of Gastrin (G-) cells. II. Nonspecific binding of immunoglobulins to G-cells by ionic interactions. Histochemistry 66:149–167Google Scholar
  8. Kidd (1963) Paired helical filaments in electron microscopy of Alzheimer's disease. Nature 197:192–193Google Scholar
  9. Lane BP, Europa DL (1965) Differential staining of ultrathin sections of Epon-embedded tissues for light microscopy. J Histochem Cytochem 13:579–582Google Scholar
  10. Puchtler H, Sweat F, Levine M (1962) On the binding of Congo red by amyloid. J Histochem Cytochem 10:355–364Google Scholar
  11. Sternberger LA (1979) Immunocytochemistry, 2nd edn. Wiley, New York Chichester Brisbane TorontoGoogle Scholar
  12. Terry RD (1963) The fine structure of neurofibrillary tangles in Alzheimer's disease. J Neuropathol Exp Neurol 22:629–642Google Scholar
  13. Wisniewski HM, Iqbal K (1980) Ageing of the brain and dementia. TINS 3:226–228Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. Probst
    • 1
  • J. Ulrich
    • 1
  • Ph. U. Heitz
    • 1
  1. 1.Dept. of Pathology of the University of BaselBaselSwitzerland

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