Acta Neuropathologica

, Volume 57, Issue 1, pp 75–79 | Cite as

Senile dementia of Alzheimer type: Astroglial reaction to extracellular neurofibrillary tangles in the hippocampus

An immunocytochemical and electron-microscopic study
  • A. Probst
  • J. Ulrich
  • Ph. U. Heitz
Short Original Communication


Two types of Alzheimer neurofibrillary tangles may be found in the hippocampus in senile dementia of the Alzheimer type. Besides classical flameshaped intraneuronal tangles, there are less compact tangles representing extracellular remnants of destroyed neurons with neurofibrillary change. Strong immunoreactivity for glial fibrillary acidic protein (GFA) was found in the second type of tangles, which was due to penetration of fine processes of fibrous astrocytes into bundles of paired helical filaments (PHF). PHF appear to be a strong stimulus for astrocytic reaction when they are not segregated from the neuropil by the neuronal cell membrane.

Key words

Senile dementia of Alzheimer type Neurofibrillary tangles Fibrous astrocytes Immunocytochemistry 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. Probst
    • 1
  • J. Ulrich
    • 1
  • Ph. U. Heitz
    • 1
  1. 1.Dept. of Pathology of the University of BaselBaselSwitzerland

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