Cancer Chemotherapy and Pharmacology

, Volume 27, Issue 5, pp 406–408 | Cite as

Pharmacokinetics of recombinant interferon alpha-C

  • Ofer Merimsky
  • Menachem Rubinstein
  • Dina Fischer
  • Abraham Danon
  • Samario Chaitchik
Short Communications Pharmacokinetics, Recombinant Interferon Alpha-C


Recombinant interferon alpha-C (rIFNα-C, Interpharm), is a new type of alpha-interferon that has a specific activity of 1–2×109 units/mg protein. The pharmacokinetics of rIFNα-C were studied in 11 patients with metastatic renal-cell carcinoma. A total of 10 million units IFNα-C were injected intramuscularly and the serum level of IFN was evaluated up to 72 h post-administration. Measurable IFN concentrations appeared in the serum as early as 0.5 h, and levels peaked at 4–6 h (Cmax=53.2±4.6 units/ml). Relatively high levels persisted for 24 h and declined thereafter with an apparent half-life of 3–4 h. The mean area under the serum-concentration curve (AUC) was 1,259±145 units h ml−1, indicating good bioavailability of the preparation from the intramuscular injection.


Carcinoma Serum Level Cancer Research Interferon Intramuscular Injection 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Ofer Merimsky
    • 1
  • Menachem Rubinstein
    • 2
  • Dina Fischer
    • 3
  • Abraham Danon
    • 4
  • Samario Chaitchik
    • 1
  1. 1.Department of OncologyTel-Aviv Sourasky Medical CenterTel-AvivIsrael
  2. 2.Department of VirologyWeizman Institute of ScienceRehovothIsrael
  3. 3.Interpharm Laboratories, Ltd.Ness ZionaIsrael
  4. 4.Department of Clinical PharmacologyBen Gurion University and Soroka Medical CenterBeer ShebaIsrael

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