Acta Neuropathologica

, Volume 50, Issue 3, pp 211–216 | Cite as

Membrane alterations in human glioblastoma

  • Werner Lubitz
  • Anne Reichert
  • Georg Birkmayer
Original Works


Plasma membrane-enriched fractions were isolated from human gliomas and brain white matter. These membrane fractions were characterized by electron microscopy and by the distribution of the membrane marker enzymes (Na+K+)-ATPase and 2′,3′-cyclic AMP-3′-phosphohydrolase. The comparison of the membranes from tumor and control material by SDS gel electrophoresis reveals an altered tumor membrane. Two proteins of a molecular weight of about 70,000 dalton and 30,000 dalton are found to be more expressed in the tumor membrane.

Key words

Glioblastoma Plasma membrane Tumor specific proteins 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Werner Lubitz
    • 1
  • Anne Reichert
    • 1
  • Georg Birkmayer
    • 1
  1. 1.Department of Cell BiologyUniversity of MunichMunich 2Federal Republic of Germany

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