Advertisement

Acta Neuropathologica

, Volume 40, Issue 2, pp 163–169 | Cite as

Hereditary “Cavitating” leucodystrophy in Dalmatian dogs

Light and electron microscopic studies
  • I. Bjerkås
Original Investigations

Summary

A recently recognised progressive disorder of central myelin in Dalmatian dogs is described. The disease is probably transmitted by autosomal recessive inheritance. The symptoms started at the age of 3–6 months and were dominated by visual deficiency and/or progressive locomotive abnormalities. Pathologically, the most consistent lesions were found bilaterally in the region of the centrum semiovale. The optic nerves were also frequently affected, the basal ganglia and spinal cord were affected infrequently. The main lesions were confined to myelin, while axons and nerve cells were spared, particularly in the early stages of the lesions. Numberous phagocytes were observed which contained engulfed myelin and other lipid breakdown products. Ultrastructurally and histochemically the disease differs from previusly described types of leucodystrophy.

Key words

Leucodystrophy Myelin Dog Histochemistry Electron microscopy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, C. W. M.: Neurohistochemistry Amsterdam-London-New York Elsevier 1965Google Scholar
  2. Aldskogius, H.: Indirect and direct Wallerian degeneration in the intramedullary root fibres of the hypoglossal nerve. An electron microscopical study in the kitten. Advanc. Anat. Embryol. Cell Biol.50, 1–77 (1974)Google Scholar
  3. Barlow, R., Purves, D., Butler, E. J., Jean Macintyre, I.: Swayback in South-East Scotland. II. Clinical, pathological and biochemical aspects. J. comp. Path.70, 411–429 (1960)Google Scholar
  4. Bennetts, H. W., Beck, A. B.: Enzootic ataxia and copper deficiency of sheep in Western Australia. Bull. Coun. sci. industr. Res. Aust.147, 1–52 (1942)Google Scholar
  5. Bignami, A., Ralston, H. J.: The cellular reaction to Wallerian degeneration in the central nervous system in the cat. Brain Res.13, 444–461 (1961)Google Scholar
  6. Crome, L., Stern, J.: Inborn lysomal enzyme deficiencies. In: Greenfield's neuropathology (eds. W. Blackwood and J. A. N. Corsellis). London: E. Arnold 1976Google Scholar
  7. Fankhauser, R., Luginbühl, H., Hartley, W. J.: Leukodystrophie vom Typus Krabbe beim Hund. Schweiz. Arch. Tierheilk.105, 198–207 (1963)Google Scholar
  8. Fletcher, T. F., Kurtz, H. J., Low, D. G.: Globoid cell leukodystrophy (Krabbe type) in the dog. J. Amer. vet. med. Ass.149, 165–172 (1966)Google Scholar
  9. Fletcher, T. F., Lee, D. G., Hammer, R. F.: Ultrastructural features of globoid-cell leukodystrophy in the dog. Amer. J. vet. Res.32, 177–181 (1971)Google Scholar
  10. Hirsch, T. H., Pfeiffer, J.: A histochemical study of the prelipoid and metachromatic degenerative product in leucodystrophy. In: Cerebral lipidoses (eds. J. N. Cumings and A. Lowenthal). Oxford: Blackwell 1957Google Scholar
  11. Howell, J. McC., Davison, A. N., Oxberry, J.: Observations on the lesions in the white matter of the spinal cord of swayback sheep. Acta neuropath. (Berl.)12, 33–41 (1969)Google Scholar
  12. Innes, J. R. M., Shearer, G. D.: “Swayback”: A demyelinating disease of lambs with affinities to Schilder's encephalitis in man. J. comp. Path.53, 1–41 (1940)Google Scholar
  13. Poser, C. M.: Diseases of the myelin sheath. In: Neuropathology; methods and diagnosis (ed. C. G. Tedeschi) Boston: Little Brown 1970Google Scholar
  14. Suzuki, K., Suzuki, K.: Disorders of sphingolipid metabolism. In: Biology of brain dysfunction. Vol. II (ed. G. E. Gaull). New York-London Plenum Press 1973Google Scholar
  15. Swank, R. L., Davenport, H. A.: Chlorate-osmic-formalin method for staining degenerating myelin. Stain Technol.10, 87–90 (1935)Google Scholar
  16. Underwood, E. J.: Trace elements in human and animal nutrition. 3rd ed. New York-San Francisco-London: Academic Press 1971Google Scholar
  17. Van den Akker, S.: A case of leucodystrophia in a dog. Folia psychiat. neerl.61, 536–539 (1958)Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • I. Bjerkås
    • 1
  1. 1.Department of PathologyVeterinary College of NorwayOslo 1Norway

Personalised recommendations