Acta Neuropathologica

, Volume 40, Issue 2, pp 163–169 | Cite as

Hereditary “Cavitating” leucodystrophy in Dalmatian dogs

Light and electron microscopic studies
  • I. Bjerkås
Original Investigations


A recently recognised progressive disorder of central myelin in Dalmatian dogs is described. The disease is probably transmitted by autosomal recessive inheritance. The symptoms started at the age of 3–6 months and were dominated by visual deficiency and/or progressive locomotive abnormalities. Pathologically, the most consistent lesions were found bilaterally in the region of the centrum semiovale. The optic nerves were also frequently affected, the basal ganglia and spinal cord were affected infrequently. The main lesions were confined to myelin, while axons and nerve cells were spared, particularly in the early stages of the lesions. Numberous phagocytes were observed which contained engulfed myelin and other lipid breakdown products. Ultrastructurally and histochemically the disease differs from previusly described types of leucodystrophy.

Key words

Leucodystrophy Myelin Dog Histochemistry Electron microscopy 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • I. Bjerkås
    • 1
  1. 1.Department of PathologyVeterinary College of NorwayOslo 1Norway

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