Summary
An experimental model of the autoimmune process was developed to study the pathophysiological and structural changes in immunomyopathies. Immune-sera derived from three muscle proteins—myofibril, myosin and actin—produced immunomyopathies for study. The pathophysiological data show that the general muscle efficiency began to decrease with the early stages of treatment and reflected a severe disorder to muscle function with the progression of time. Parallel changes were also observed by light microscopy.
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Literature
Arnason, B., Samaha, F. J.: Studies in progress on the stimulation of myasthenia gravis like states in experimental animals by immunologic means. Paper read at NIH meeting on experimental models of myasthenia gravis, Bethesda (1967)
Bárány, M., Biró, N. A., Molnár, J., Straub, F. B.: Darstellung enzymfreien Actins durch Umfallung mit Magnesium. Acta physiol. Acad. Sci. hung.5, 369–381 (1954)
Dawkins, R. L.: Experimental myositis associated with hypersensitivity to muscle. J. Path. Bact.90, 618–625 (1965)
Douglas, S. D., Gottlieb, A. J., Strauss, A. J. L., Spicer, S. S.: Electron microscopic localization of striated muscle binding factor in myasthenia gravis by ferritin labeled antibody. Fed. Proc.24, 370 (Abstr. 1335) (1965)
Frenkl, R., Csalay, L.: The effect of regular muscle activity on the function of adrenal cortex in rats (in Hung.). Kisérl. Orvostud.14, 473–478 (1962)
Gornall, A. G., Bardawill, C. J., David, M. M.: Determination of serum proteins by means of the biuret reaction. J. biol. Chem.177, 751–766 (1949)
Goldstein, G., Whittingham, S.: Experimental auto-immune thymitis. An animal model of human myasthenia gravis. Lancet1966 II, 315–318
Gottlieb, A. J., Douglas, S. D., Strauss, A. J. L., Spicer, S.: Ultrastructural localization of gamma-globulin binding to skeletal muscle. Ann. N. Y. Acad. Sci.135, 638–643 (1966)
Grob, D., Namba, T., Sato, T., Klein, D. R.: Effect on skeletal muscle of serum of myasthenic patients and of rabbits immunized with muscle constituents. Fed. Proc.24, 693 (1965)
Kakulas, B. A.: Destruction of differentiated muscle cultures. J. Path. Bact.91, 495–503 (1955)
Kawanami, S., Mori, R.: Experimental myasthenia in mice (The role of the thymus and lymphoid cells). Clin. exp. Immunol.12, 447–454 (1972)
Knoll, J.: Pharmacology (in Hung.). Med. Konyvkiado218 (1965)
Masugi, M.: Über die experimentelle Glomerulonephritis durch das spezifische Antinierenserum. Beitr. path. Anat.92, 429–467 (1934)
McFarlin, E. D., Johnson, J. S., Seymour, W. F. K.: Antimuscle factor and antinuclear factor in patient with myasthenia gravis. J. Immunol.101, 104–110 (1968)
Mendell, J. R., Whitaker, J. N., Engel, W. K.: The skeletal muscle binding site of antistriated muscle antibody in myasthenia gravis; an electron microscopic immunohistochemical study using peroxidase conjugated antibody fragment. J. Immunol.111, 847–856 (1973)
Miescher, P. A., Muller-Eberhard, H. I.: Testbook of immunopathology. New York-London: Grune and Stratton 1969
Mommaerts, W. F. H. M.: Reversible polymerization and ultracentrifugal purification of actin. J. biol. Chem.188, 559–565 (1951)
Nastuk, W. L., Kessley, H. J., Grynbaum, A., Smith, M., Herman, C., Jr.: Immunological changes following thymectomy in myasthenia gravis. Arch. Neurol. (Chic.)15, 1–12 (1966)
Oudin, J.: The genetic control of immunoglobulin synthesis. Proc. roy. Soc. B166, 207–221 (1966)
Pepe, F. A.: Some aspects of the structural organization of the myofibril as revealed by antibody staining methods. J. Cell Biol.28, 505–525 (1966)
Perry, S. V.: The bound nucleotide of the isolated myofibril. Biochem. J.51, 495–499 (1952)
Portzehl, H., Schramm, G., Weber, H. H.: Actomyosin und seine Komponenten. I. Mitt. Z. Naturforsch.5, 61–69 (1950)
Rook, H., Wilkinson, D. S., Ebling, F. J. G.: Textbook of Dermatology, 3rd ed. (1967)
Sagan, Z.: The application of rivanol for serum transferrin and immunoglobulin G. determination. Clin. chim. Acta21, 225–230 (1968)
Strauss, A. J. L., Deitch, A., Hsu, K.: Further observations on the localization of a muscle binding, complement fixing serum globulin fraction in myasthenia gravis. Fed. Proc.20, 38 (1961)
Strauss, A. J. L., Kemp, P. G., Douglas, S. D.: Myasthenia gravis. Lancet1966I, 772–773
Strauss, A. J. L., Kemp, P. G., Jr.: Serum autoantibodies in myasthenia gravis and thymoma, selective affinity for I-bands of striated muscle as a guide to identification of antigen. J. Immunol.99, 945–953 (1967)
Strauss, A. J. L., Smith, C. W., Case, G. W., van der Geld, H. W. R., McFarlin, D. E., Barlow, M.: Further studies on the specificity of presumed immuno associations of myasthenia gravis and consideration of possible pathogenic implications. Ann. N. Y. Acad. Sci.135, 557–579 (1966)
Tal, C., Liban, E.: Experimental production of muscular dystrophy-like lesions in rabbits and guinea-pigs by an auto-immune process. Brit. J. exp. Path.43, 525–529 (1962)
Tolnai, G.: Muscle lesions in mice injected with isologous and homologous muscle extracts. Nature (Lond.)212, 1429–1431 (1966)
Van Der Geld, H., Feltkamp, T. E., Van Loghem, J. J., Oosterhuis, H. J. G. H.: Reactivity of myasthenia gravis serum gammaglobulin with skeletal muscle and thymus demonstrated by immunofluorescence. Proc. Soc. exp. Biol. (N. Y.)115, 782–785 (1964)
Van De Velde, R. L., Friedman, N. B.: Thymic myoid cells and myasthenia gravis. Amer. J. Path.59, 347–368 (1970)
Weir, D. M.: Immunoferritin technique for the identification of antigen by electron microscopy in experimental immunology. Oxford-Edinbourgh: Blackwell Sci. Publ. 1967
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Korényi-Both, A., Kelemen, G. Damage of skeletal muscle in rats by immunoglobulins. Acta Neuropathol 34, 199–206 (1976). https://doi.org/10.1007/BF00688675
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DOI: https://doi.org/10.1007/BF00688675