Acta Neuropathologica

, Volume 34, Issue 3, pp 199–206 | Cite as

Damage of skeletal muscle in rats by immunoglobulins

I. Pathophysiological data and lightmicroscopic observations
  • A. Korényi-Both
  • Gabriella Kelemen
Original Investigations


An experimental model of the autoimmune process was developed to study the pathophysiological and structural changes in immunomyopathies. Immune-sera derived from three muscle proteins—myofibril, myosin and actin—produced immunomyopathies for study. The pathophysiological data show that the general muscle efficiency began to decrease with the early stages of treatment and reflected a severe disorder to muscle function with the progression of time. Parallel changes were also observed by light microscopy.

Key words

Immunomyopathy Muscle disease Experimental muscle pathology Pathophysiology Morphology 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • A. Korényi-Both
    • 1
    • 2
    • 3
  • Gabriella Kelemen
    • 1
    • 2
  1. 1.1st Institute of PathologySemmelweis Medical UniversityBudapestHungary
  2. 2.Biochemical Group of Eötvös Loránd UniversityBudapestHungary
  3. 3.Department of PathologyThe Genesee HospitalRochesterNew YorkUSA

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