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Acta Neuropathologica

, Volume 58, Issue 4, pp 275–278 | Cite as

Permanganate oxidation of senile cerebral amyloid and its relationship to AA protein

  • J. M. Powers
  • L. Sullivan
  • C. J. Rosenthal
Original Works

Summary

Immunoreactivity for AA protein was rarely detected in briefly fixed amyloid of senile plaques and dyshoric angiopathy, but was not observed in Congophilic angiopathy. Plaque and dyshoric amyloid exhibited variable sensitivity to permanganate oxidation; Congophilic angiopathy was resistant to oxidation. In contrast to systemic amyloid composed of AA protein, the rare immunoreactivity of senile cerebral amyloid was lost with prolonged fixation. This study demonstrates that the fibrillar protein of senile cerebral amyloid differs from that of systemic amyloid of AA type.

Key words

AA protein Amyloid Oxidation Immunoperoxidase Senile brain 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • J. M. Powers
    • 1
  • L. Sullivan
    • 2
  • C. J. Rosenthal
    • 3
  1. 1.Dept. of Pathology (Neuropathology)Medical University of South CarolinaCharlestonUSA
  2. 2.Dept. of Basic and Clinical Immunology and MicrobiologyMedical University of South CarolinaCharlestonUSA
  3. 3.Dept. of Medicine, Downstate Medical CenterState University of New YorkBrooklynUSA

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