Acta Neuropathologica

, Volume 40, Issue 1, pp 91–93 | Cite as

Herpes simplex encephalitis: an autopsy case with isolation of type 1 herpes simplex virus

  • Shozo Miyake
  • Shigeru Yasuraoka
  • Yasuyoshi Kiryu
  • Eijiro Satoyoshi
  • Takeshi Kurata
  • Yuzo Aoyama
Short Original Communications
  • 46 Downloads

Summary

An adult case of herpes simplex encephalitis was studied after autopsy. Postmortem examination revealed necrotizing encephalitis associated with Cowdry type A intranuclear inclusion bodies in glial cells. Herper simplex virus type 1 was isolated from the removed brain. Herpes simplex virus antigens were detected diffusely in wide areas of the brain by immunofluorescent test and viral particles characteristic to herpes simplex virus were demonstrated by electron microscopy. There was an apparent discrepancy between severity of histological changes and distribution of virus antigen.

Key words

Herpes simplex virus Herpes simplex encephalitis Herpes simplex virus type 1 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Shozo Miyake
    • 1
  • Shigeru Yasuraoka
    • 1
  • Yasuyoshi Kiryu
    • 1
  • Eijiro Satoyoshi
    • 2
  • Takeshi Kurata
    • 3
  • Yuzo Aoyama
    • 3
  1. 1.Department of Internal MedicineNippon Kokan HospitalKawasakiJapan
  2. 2.Department of Internal MedicineToho University, School of MedicineTokyoJapan
  3. 3.Department of Pathology, Institute of Medical ScienceUniversity of TokyoTokyoJapan

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