Acta Neuropathologica

, Volume 38, Issue 2, pp 153–158 | Cite as

The pathophysiology of the blood-brain barrier dysfunction induced by severe hypercapnia and by epileptic brain activity

  • Barbro Johansson
  • Bengt Nilsson
Original Investigations


The cerebrovascular permeability to protein was studied in hypercapnic rats and in rats with epileptic seizures induced by bicuculline and homocysteine. Despite the differences of the basic pathophysiological mechanisms involved in these models, the blood-brain barrier (BBB) dysfunction was clearly related to the combined effects of high blood pressure and cerebral vasodilatation, thus indicating mechanical factors to be predominantly involved. The BBB changes were most frequent in central and basal regions in contrast to those induced by acute hypertension, which are most common in cortical areas.

Key words

Blood-brain barrier Arterial hypertension Protein tracers Hypercapnia Epileptic brain activity Bicuculline Homocysteine Phenotalamine 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Barbro Johansson
    • 1
    • 2
  • Bengt Nilsson
    • 1
    • 2
  1. 1.Department of NeurologyUniversity of Göteborg, Sahlgren HospitalGöteborg
  2. 2.Brain Research Laboratory, E-blocketUniversity HospitalLundSweden

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