Acta Neuropathologica

, Volume 21, Issue 3, pp 224–231 | Cite as

Early Pick's disease

A light and ultrastructural study
  • Javad Towfighi
Original Investigations


A case of asymptomatic Pick's disease is reported. The pathologic findings were limited to the amygdala, Ammon's horns, hippocampal gyri and right fusiform gyrus. Numerous Pick bodies, Hirano bodies and granulovacuolar degeneration of neurons were found. Pick bodies ultrastructurally were composed of randomly arranged short osmiophilic filaments of 125 to 200 Å diameter which did not contain definite lumen.

This case was considered to represent an “early Pick's” disease and as far as we are aware, no such case has been reported in literature.

Key words

Pick's Disease Pick Bodies Hirano Bodies 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Javad Towfighi
    • 1
  1. 1.Division of Neuropathology (Departments of Neurology and Pathology)University of Pennsylvania School of MedicinePhiladelphiaUSA

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