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Acta Neuropathologica

, Volume 21, Issue 3, pp 224–231 | Cite as

Early Pick's disease

A light and ultrastructural study
  • Javad Towfighi
Original Investigations

Summary

A case of asymptomatic Pick's disease is reported. The pathologic findings were limited to the amygdala, Ammon's horns, hippocampal gyri and right fusiform gyrus. Numerous Pick bodies, Hirano bodies and granulovacuolar degeneration of neurons were found. Pick bodies ultrastructurally were composed of randomly arranged short osmiophilic filaments of 125 to 200 Å diameter which did not contain definite lumen.

This case was considered to represent an “early Pick's” disease and as far as we are aware, no such case has been reported in literature.

Key words

Pick's Disease Pick Bodies Hirano Bodies 

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References

  1. Hirano, A.: Pathology of amyotrophic lateral sclerosis. In: D. C. Gajdusek, C. J. Gibbs, and M. Alpers (Eds.): Slow, latent and temperate virus infections, NINDB Monograph No. 2, N. I. H., pp. 23–37 (1965).Google Scholar
  2. —, Dembitzer, H. M., Kurland, L. T., Zimmerman, H. M.: The fine structure of some intraganglionic alterations. J. Neuropath. exp. Neurol.27, 167–182 (1968).Google Scholar
  3. —, Tuazon, R., Zimmerman, H. M.: Neurofibrillary changes, granulovacuolar bodies and argentophilic globules observed in tuberous sclerosis. Acta neuropath.11, 257–261 (1968).Google Scholar
  4. Mansvelt, J. Van: Pick's disease, a syndrome of lobar cerebral atrophy. Clinico Anatomical and Histopathological Types. Enschede: M. J. v. d. Loeff 1954.Google Scholar
  5. Rewcastle, N. B., Ball, M. J.: Electron microscopic structure of the “inclusion bodies” in Pick's disease. Neurology (Minneap.)18, 1205–1213 (1968).Google Scholar
  6. Schochet, S. S., Jr., Lampert, P. W., Lindenberg, R.: Fine structure of the Pick and Hirano bodies in a case of Pick's disease. Acta neuropath. (Berl.)11, 330–337 (1968).Google Scholar
  7. Smythies, J. R.: Brain mechanisms and behavior. Sec. Ed. Oxford-Edinburgh: Blackwell Scientific Pub. 1970.Google Scholar
  8. Terry, R. D., Wisniewski, H., Coblentz, J.: An ultrastructural study of Pick's disease. Arch. Neurol. (Chic.)26, 97–108 (1972).Google Scholar
  9. Williams, H. W.: The peculiar cells of Pick's disease. Arch. Neurol. Psychiat. (Chic.)34, 508–519 (1935).Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Javad Towfighi
    • 1
  1. 1.Division of Neuropathology (Departments of Neurology and Pathology)University of Pennsylvania School of MedicinePhiladelphiaUSA

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