Acta Neuropathologica

, Volume 61, Issue 1, pp 61–64 | Cite as

Intraneural injection of lymphocytes in experimental allergic neuritis

  • J. J. Gilbert
  • T. E. Feasby
  • A. F. G. Hahn
Original Works

Summary

Passive transfer of experimental allergic neuritis (EAN) lymph node cells (LNC) by intraneural injection did not produce significant demyelination. EAN-LNC stimulated with myelin in vitro produced mild demyelination while those incubated with Concanavalin A had no effect. The lack of demyelination by unstimulated EAN-LNC is in contrast to the marked demyelination produced by intraneural injection of EAN serum. The mononuclear cell infiltration and demyelination of classical EAN seem to require both cellular and humoral immune responses.

Key words

Experimental allergic neuritis Lymphocytes Passive transfer Intraneural injection 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • J. J. Gilbert
    • 1
    • 2
    • 3
  • T. E. Feasby
    • 1
    • 2
    • 3
  • A. F. G. Hahn
    • 1
    • 2
    • 3
  1. 1.Dept. of Pathology (Neuropathology)Victoria HospitalLondonCanada
  2. 2.Dept. of Clinical Neurological SciencesUniversity HospitalLondonCanada
  3. 3.University of Western OntarioLondonCanada

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