Acta Neuropathologica

, Volume 69, Issue 3–4, pp 341–342 | Cite as

Neurotrophic factor for central cholinergic neurones is present in both normal and Alzheimer brain tissue

  • C. K. Atterwill
  • D. M. Bowen
Short Original Communications


Reaggregate cultures of foetal rat brain grown in a serum-free medium were used to determine the presence or absence of cholinergic neurotrophic factors in Alzheimer's disease brain tissue. These preliminary data show that both normal and Alzheimer's disease brain contain factors which elevate choline acetyltransferase activity in the reaggregate cultures.

Key words

Rat brain reaggregate cultures Choline acetyltransferase Neurotrophic factors Alzheimer's disease 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • C. K. Atterwill
    • 1
  • D. M. Bowen
    • 2
  1. 1.Dept. ToxicologySmith, Kline and French Research LtdWelwynUK
  2. 2.Department of NeurochemistryThe Institute of NeurologyLondonUK

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