Acta Neuropathologica

, Volume 78, Issue 2, pp 176–182 | Cite as

Histopathological study of alobar holoprosencephaly

1. Abnormal laminar architecture of the telencephalic cortex
  • M. Mizuguchi
  • Y. Morimatsu
Regular Papers


Abnormal architecture of the telencephalic cortex was studied in six autopsy specimens of alobar holoprosencephaly by histopathological, electron microscopic and immunohistochemical methods. Several common abnormalities are described and their significance discussed. In all of the specimens, the cortices showed excessive thickness and abnormal lamination with a middle cellular layer and an external sparse layer, indicating disturbance of neuronal migration. Neurons of the external sparse layer were segmented into irregularly arranged groups, suggesting disturbance of tisse organization. In three specimens, the internal pyramidal layer contained numerous abnormal glomerular structures which consisted of fine dendrites and axons.

Key words

Holoprosencephaly Pathology Cerebral cortex Neuronal migration Glomerulus 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • M. Mizuguchi
    • 1
  • Y. Morimatsu
    • 2
  1. 1.Department of Neuropathology, Institute of Brain Research, Faculty of MedicineThe University of TokyoBunkyo-ku, TokyoJapan
  2. 2.Department of Clinical NeuropathologyTokyo Metropolitan Institute for NeurosciencesFuchu, TokyoJapan

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