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Microangiopathy of endoneurial vessels in hypoxemic chronic obstructive pulmonary disease (COPD)

A quantitative ultrastructural study

Acta Neuropathologica volume 78, pages 388–395 (1989)Cite this article

Summary

A peripheral neuropathy has been reported in patients with chronic respiratory insufficiency due to chronic obstructive pulmonary disease (COPD). It is mainly characterized by axonal degeneration, secondary demyelination and abnormal endoneurial vessels. The pathogenesis of these lesions remains obscure. To investigate whether relationships exist between neuritic and vascular lesions, a qualitative and quantitative ultrastructural study was performed on nerve biopsies in 13 patients with chronic respiratory insufficiency due to COPD, and in 9 normal controls without pulmonary lesions. A computer-assisted multiple regression analysis taking into account clinical, electrophysiological, biological and morphometric parameters was performed. Statistically significant differences in the endoneurial structure of microvessels were: (1) thickening of the basement membrane; (2) narrowing of the lumen; (3) mural pericytic debris deposits, occurring in the COPD group. In the latter, hypercapnia correlated positively with nerve fibers lesions (P=0.03) and endothelial area (P=0.03). No correlations were found between age and other parameters. These findings highlight the fact that the microangiopathy in peripheral nerves in patients with COPD may be diffuse and essentially due to hypoxia and reduction in blood flow, as in diabetic neuropathy.

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Affiliations

  1. Department of Cellular Pathology, University School of Medicine, Albert Michallon Hospital, BP 217X, F-38043, Grenoble Cedex, France

    P. Stoebner & P. Mezin

  2. Department of Electrophysiology, University School of Medicine, Albert Michallon Hospital, BP 217X, F-38043, Grenoble Cedex, France

    A. Vila

  3. Department of Pneumology, Grenoble, University School of Medicine, Albert Michallon Hospital, BP 217X, F-38043, Grenoble Cedex, France

    B. Paramelle

  4. Center for Toxicological Research, 905 route de Saran, BP 255, Gidy, F-45403, Fleury les Aubrais Cedex, France

    R. Grosse

  5. Department of Pathology, Edouard Herriot Hospital, Place d'Arsonval, F-69003, Lyon, France

    N. Kopp

Authors
  1. P. Stoebner
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  2. P. Mezin
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  3. A. Vila
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  4. R. Grosse
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  5. N. Kopp
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  6. B. Paramelle
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Stoebner, P., Mezin, P., Vila, A. et al. Microangiopathy of endoneurial vessels in hypoxemic chronic obstructive pulmonary disease (COPD). Acta Neuropathol 78, 388–395 (1989). https://doi.org/10.1007/BF00688175

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  • DOI: https://doi.org/10.1007/BF00688175

Key words

  • Axonal degeneration
  • Hypercapnia
  • Microangiopathy
  • Peripheral neuropathy
  • Peroneal nerve morphometry