Acta Neuropathologica

, Volume 76, Issue 2, pp 204–207 | Cite as

Retinal S-antigen immunoreactivity in medulloblastomas

  • J. M. Bonnin
  • E. Perentes
Regular Papers


A series of 16 cerebellar medulloblastomas were studied immunohistochemically using a four-step immunoperoxidase (PAP) method and a monoclonal antibody (MAbA9-C6) which defines an epitope of the retinal S-antigen, a protein known to occur in retinal photoreceptor cells and pinealocytes of the pineal gland as well as in retinoblastomas, pineocytomas and pineoblastomas. Immunopositivity was demonstrated in a variable number of tumor cells in 50% of the cases. This finding may be an indication of a differentiation potential of medulloblastomas along the photoreceptor cell lineage. Alternatively, it may simply indicate the non-specificity of the retinal antigen in the neoplastic state.

Key words

S-Antigen Monoclonal antibodies Cerebellar medulloblastoma Photoreceptor cells 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • J. M. Bonnin
    • 1
  • E. Perentes
    • 2
  1. 1.Division of Anatomic Pathology/NeuropathologyUniversity of Alabama School of MedicineBirminghamUSA
  2. 2.Division of NeuropathologyUniversity of Virginia School of MedicineCharlottesvilleUSA

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