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Acta Neuropathologica

, Volume 53, Issue 3, pp 173–179 | Cite as

Proliferation of schwann cells in tellurium-induced demyelination in young rats

A radioautographic and teased nerve fiber study
  • G. Said
  • S. Duckett
  • B. Sauron
Original Works

Summary

This is a study of DNA synthesis of Schwann cells during the demyelination and the remyelination of peripheral nerves secondary to the intoxication of young rats with tellurium (Te). The3H-thymidine uptake of Schwann cells begins on day 4, reaches a zenith on day 7, and ends before day 20 on the Te diet despite continuation of the diet.

The chronology of pathologic events is that myelin breakdown leading to segmental demyelination occurs first, followed within 24–48 h by the appearance of paralysis and by the beginning of DNA synthesis by the Schwann cells. A quantitative study on isolated nerve fiber preparations showed that more Schwann cells are produced than necessary to cope with the remyelination and that only one of four to six Schwann cells present in the demyelinated area at day 12 will participate in the remyelinating process.

Key words

Segmental demyelination DNA synthesis Schwann cells Tellurium 

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References

  1. Abercombie M, Johnson ML (1946) Quantitative histology of Wallerian degeneration; nuclear population in rabbit sciatic nerve. J Anat (Lond) 80:37–50Google Scholar
  2. Asbury AK (1967) Schwann cell proliferation in developing mouse sciatic nerve: a radioautographic study. J Cell Biol 34:735–743Google Scholar
  3. Asbury AK (1975) Biology of Schwann cells. In: Dyck PJ, Thomas PK, Lambert EH (eds). Peripheral neuropathy, vol 1. Saunders, Philadelphia, pp 201–212Google Scholar
  4. Asbury AK, Arnason BG (1968) Experimental allergic neuritis. J Neuropathol Exp Neurol 27:581–590Google Scholar
  5. Berthold CH, Skoglund S (1968) Postnatal development of feline paranodal myelin sheat segments. II. Electron microscopy. Acta Soc Med Upsal 73:127–144Google Scholar
  6. Bradley WG, Asbury AK (1970) Duration of synthesis phase in neurilemma cells in mouse sciatic nerve during degeneration. Exp Neurol 26:275–282Google Scholar
  7. Diner O (1965) Les cellules de Schwann en mitose et leurs rapports avec les axones au cours du developpement du nerf sciatique chez le rat. C R Acad Sci Paris 261:1731–1734Google Scholar
  8. Duckett S, Said G, Streletz LG, White RG, Galle P (1979) Tellurium induced neuropathy: correlative physiological, morphological, and electron microprobe studies. Neuropathol Appl Neurobiol 5:265–279Google Scholar
  9. Friede RL, Johnstone MA (1967) Responses of thymidine labeling of nuclei in gray matter and nerve following sciatic transection. Acta Neuropathol (Berl) 7:218–231Google Scholar
  10. Friede RL, Samorajski T (1968) Myelin formation in the sciatic nerve of the rat. J Neuropathol Exp Neurol 27:546–570Google Scholar
  11. Hall SM, Gregson NA (1978) The effect of 5-bromodeoxyuridine on remyelination in the peripheral nervous system of the mouse. Neuropathol Appl Neurobiol 4:117–127Google Scholar
  12. Lampert P, Garro F, Pentschew A (1970) Tellurium neuropathy. Acta Neuropathol (Berl) 15:308–317Google Scholar
  13. Lubinska L (1958) Short internodes “intercalated” in nerve fibers. Acta Biol Exp (Warszawa) 18:117–136Google Scholar
  14. Lubinska L (1961) Sedentary and migratory states of Schwann cells. Exp Cell Res [Suppl] 8:74–90Google Scholar
  15. Peters A, Muir AR (1959) The relationship between axons and Schwann cells during development of peripheral nerves in the rat. J Exp Physiol 44:117–125Google Scholar
  16. Raine CS (1977) Schwann cell responses during recurrent demyelination and their relevance to onion bulb formation. Neuropathol Appl Neurobiol 3:453–470Google Scholar
  17. Webster H de F, Martin JR, O'Connell NF (1973) The relationship between interphase Schwann cells and axons before myelination: a quantitative electron microscopy study. Devel Biol 3:401–419Google Scholar
  18. Weinberg HJ, Spencer PS (1976) Studies on the control of myelogenesis. III. Evidence for neuronal regulation of myelination. Brain Res 113:363–378Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • G. Said
    • 1
  • S. Duckett
    • 2
  • B. Sauron
    • 1
  1. 1.Faculté de Médecine Paris Sud, Service de NeurologieCentre Hospitalier de BicêtreLe Kremlin BicêtreFrance
  2. 2.Jefferson Medical College of the Thomas Jefferson UniversityPhiladelphiaUSA

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