Skip to main content
Log in

Proliferation of schwann cells in tellurium-induced demyelination in young rats

A radioautographic and teased nerve fiber study

  • Original Works
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

This is a study of DNA synthesis of Schwann cells during the demyelination and the remyelination of peripheral nerves secondary to the intoxication of young rats with tellurium (Te). The3H-thymidine uptake of Schwann cells begins on day 4, reaches a zenith on day 7, and ends before day 20 on the Te diet despite continuation of the diet.

The chronology of pathologic events is that myelin breakdown leading to segmental demyelination occurs first, followed within 24–48 h by the appearance of paralysis and by the beginning of DNA synthesis by the Schwann cells. A quantitative study on isolated nerve fiber preparations showed that more Schwann cells are produced than necessary to cope with the remyelination and that only one of four to six Schwann cells present in the demyelinated area at day 12 will participate in the remyelinating process.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Abercombie M, Johnson ML (1946) Quantitative histology of Wallerian degeneration; nuclear population in rabbit sciatic nerve. J Anat (Lond) 80:37–50

    Google Scholar 

  • Asbury AK (1967) Schwann cell proliferation in developing mouse sciatic nerve: a radioautographic study. J Cell Biol 34:735–743

    Google Scholar 

  • Asbury AK (1975) Biology of Schwann cells. In: Dyck PJ, Thomas PK, Lambert EH (eds). Peripheral neuropathy, vol 1. Saunders, Philadelphia, pp 201–212

    Google Scholar 

  • Asbury AK, Arnason BG (1968) Experimental allergic neuritis. J Neuropathol Exp Neurol 27:581–590

    Google Scholar 

  • Berthold CH, Skoglund S (1968) Postnatal development of feline paranodal myelin sheat segments. II. Electron microscopy. Acta Soc Med Upsal 73:127–144

    Google Scholar 

  • Bradley WG, Asbury AK (1970) Duration of synthesis phase in neurilemma cells in mouse sciatic nerve during degeneration. Exp Neurol 26:275–282

    Google Scholar 

  • Diner O (1965) Les cellules de Schwann en mitose et leurs rapports avec les axones au cours du developpement du nerf sciatique chez le rat. C R Acad Sci Paris 261:1731–1734

    Google Scholar 

  • Duckett S, Said G, Streletz LG, White RG, Galle P (1979) Tellurium induced neuropathy: correlative physiological, morphological, and electron microprobe studies. Neuropathol Appl Neurobiol 5:265–279

    Google Scholar 

  • Friede RL, Johnstone MA (1967) Responses of thymidine labeling of nuclei in gray matter and nerve following sciatic transection. Acta Neuropathol (Berl) 7:218–231

    Google Scholar 

  • Friede RL, Samorajski T (1968) Myelin formation in the sciatic nerve of the rat. J Neuropathol Exp Neurol 27:546–570

    Google Scholar 

  • Hall SM, Gregson NA (1978) The effect of 5-bromodeoxyuridine on remyelination in the peripheral nervous system of the mouse. Neuropathol Appl Neurobiol 4:117–127

    Google Scholar 

  • Lampert P, Garro F, Pentschew A (1970) Tellurium neuropathy. Acta Neuropathol (Berl) 15:308–317

    Google Scholar 

  • Lubinska L (1958) Short internodes “intercalated” in nerve fibers. Acta Biol Exp (Warszawa) 18:117–136

    Google Scholar 

  • Lubinska L (1961) Sedentary and migratory states of Schwann cells. Exp Cell Res [Suppl] 8:74–90

    Google Scholar 

  • Peters A, Muir AR (1959) The relationship between axons and Schwann cells during development of peripheral nerves in the rat. J Exp Physiol 44:117–125

    Google Scholar 

  • Raine CS (1977) Schwann cell responses during recurrent demyelination and their relevance to onion bulb formation. Neuropathol Appl Neurobiol 3:453–470

    Google Scholar 

  • Webster H de F, Martin JR, O'Connell NF (1973) The relationship between interphase Schwann cells and axons before myelination: a quantitative electron microscopy study. Devel Biol 3:401–419

    Google Scholar 

  • Weinberg HJ, Spencer PS (1976) Studies on the control of myelogenesis. III. Evidence for neuronal regulation of myelination. Brain Res 113:363–378

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This study was supported by funds from NIH grant NS-12092 and from the Faculté de Médecine Paris-Sud

Rights and permissions

Reprints and permissions

About this article

Cite this article

Said, G., Duckett, S. & Sauron, B. Proliferation of schwann cells in tellurium-induced demyelination in young rats. Acta Neuropathol 53, 173–179 (1981). https://doi.org/10.1007/BF00688019

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00688019

Key words

Navigation