Acta Neuropathologica

, Volume 52, Issue 2, pp 111–118 | Cite as

Morphometric evaluation of primary sensory neurons in experimental p-bromophenylacetylurea intoxication

  • Akio Ohnishi
  • Masato Ikeda
Original Works

Summary

To evaluate the three-dimensional pathology of lumbar primary sensory neurons in p-bromophenylacetylurea intoxication, the number and size distribution of neurons and of myelinated fibers were evaluated at the L-6 spinal ganglion level and at proximal and distal levels of sural nerve and thoracic (proximal) and cervical (distal) levels of Goll's tract, respectively, 2 and 6 weeks after the intoxication in rats. The number and size distribution of ganglion neuron cell bodies were not significantly different between intoxicated and control rats. The distal level of sural nerve had, significantly fewer large myelinated fibers than did control, and a significantly higher frequency of fibers undergoing degeneration. Proximal levels of sural nerve showed similar, but less severe changes. Similarly, the myelinated fibers of Goll's tract were significantly more affected at cervical than at thoracic level. Therefore, by morphometric criteria both centrally and peripherally directed myelinated fibers are most affected distally and less affected proximally while neuron cell bodies are not affected at all. These three-imensional morphological changes must be taken into consideration in formulating possible mechanisms for the development of this neuropathy.

Key words

Primary sensory neuron Neuropathy Morphometry Para-bromophenylacetylurea Neurotoxins 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Akio Ohnishi
    • 1
  • Masato Ikeda
    • 2
  1. 1.Department of Neuropathology, Neurological InstituteKyushu UniversityFukuokaJapan
  2. 2.Department of Public Health, Faculty of MedicineKyushu UniversityFukuokaJapan

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