Neurofibrillary degeneration of nerve cells after intracerebral injection of aluminium cream


Intracerebral administration of aluminium cream (aluminium hydroxide) in rabbits resulted in the development of pathological EEG, convulsive seizures, paresis of the extremities and neuronal changes consisted in a focal clearings in the cytoplasm filled by neurofibrillary tangles. In principle, the topography of the neurofibrillary changes was the same as that observed byKlatzo, Wiśniewski andStreicher in rabbits after injection of aluminium phosphate.


Intracerebrale Applikation von Aluminiumpaste (Aluminiumoxyd) bei Kaninchen führte zum Auftreten von pathologischen EEG-Veränderungen, Krampf-anfällen, Extremitätenparesen sowie von Nervenzellveränderungen in Form fokaler Cytoplasmaaufhellungen, die von verplumpten Neurofibrillen erfüllt sind. Die Topographie der neurofibrillären Veränderungen entsprach grundsätzlich den Beobachtungen vonKlatzo, Wiśniewski u.Streicher an Kaninchen nach Injektion von Aluminiumphosphat.

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This work was supported by grand PL 480, agreement No. 227706 sponsored by the United States Public Health Service.

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Wiśniewski, H., Karczewski, W. & Wiśniewska, K. Neurofibrillary degeneration of nerve cells after intracerebral injection of aluminium cream. Acta Neuropathol 6, 211–219 (1966).

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  • Status Epilepticus
  • Epileptic Seizure
  • Aluminium Hydroxide
  • Neurofibrillary Tangle
  • Convulsive Seizure