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Acta Neuropathologica

, Volume 6, Issue 3, pp 211–219 | Cite as

Neurofibrillary degeneration of nerve cells after intracerebral injection of aluminium cream

  • Henryk Wiśniewski
  • Witold Karczewski
  • Krystyna Wiśniewska
Original Investigation

Summary

Intracerebral administration of aluminium cream (aluminium hydroxide) in rabbits resulted in the development of pathological EEG, convulsive seizures, paresis of the extremities and neuronal changes consisted in a focal clearings in the cytoplasm filled by neurofibrillary tangles. In principle, the topography of the neurofibrillary changes was the same as that observed byKlatzo, Wiśniewski andStreicher in rabbits after injection of aluminium phosphate.

Keywords

Status Epilepticus Epileptic Seizure Aluminium Hydroxide Neurofibrillary Tangle Convulsive Seizure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Intracerebrale Applikation von Aluminiumpaste (Aluminiumoxyd) bei Kaninchen führte zum Auftreten von pathologischen EEG-Veränderungen, Krampf-anfällen, Extremitätenparesen sowie von Nervenzellveränderungen in Form fokaler Cytoplasmaaufhellungen, die von verplumpten Neurofibrillen erfüllt sind. Die Topographie der neurofibrillären Veränderungen entsprach grundsätzlich den Beobachtungen vonKlatzo, Wiśniewski u.Streicher an Kaninchen nach Injektion von Aluminiumphosphat.

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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • Henryk Wiśniewski
    • 1
    • 2
  • Witold Karczewski
    • 1
    • 2
  • Krystyna Wiśniewska
    • 1
    • 2
  1. 1.The Institute of Neuropathology Laboratory of ElectrophysiologyPolish Academy of SciencesWarsaw
  2. 2.Institute of Experimental Pathology, Laboratory of ElectrophysiologyPolish Academy of SciencesWarsaw

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