Acta Neuropathologica

, Volume 67, Issue 3–4, pp 322–325 | Cite as

Holoprosencephaly in a bovine calf

  • D. -Y. Cho
  • D. H. Zeman
  • J. E. Miller
Short Original Communications


Holoprosencephaly, a rare brain malformation previously unreported in the bovine species, was observed in a female Hereford calf. The malformation was characterized by lack of the longitudinal cerebral fissure and the falx cerebri with fusion of the cerebral hemispheres and a single hydrocephalically dilated lateral ventricle, absence of olfactory bulbs and nerves, corpus callosum and septum pellucidum, and heterotopia. The face was flat. There were mild ocular hypotelorism and severe microphthalmia. The morphological features of this bovine case were compared to those of human infants, and various possible etiologic factors and pathogenesis were discussed.

Key words

Prosencephalon cleavage failure Fused cerebral hemispheres Absent longitudinal fissure Holoprosencephaly Bovine 


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  1. Binns W, Keeler RF (1972) Congenital deformities in lambs, calves, and goats resulting from maternal ingestion of Veratrum californicum: Hare lip, cleft palate, ataxia, and hypoplasia of metacarpal and metarsal bones. Clin Toxicol 5:245–261Google Scholar
  2. Binns W, Thacker EJ, James LF, Huffman WT (1959) A congenital cyclopian-type malformation in lambs. J Am Vet Med Assoc 134:180–183Google Scholar
  3. Binns W, Anderson WA, Sullivan DJ (1960) Further observations on a congenital cyclopian-type malformation in lambs. J Am Vet Med Assoc 137:515–521Google Scholar
  4. Binns W, James LF, Shupe JL, Everett G (1963) A congential cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum californicum. Am J Vet Res 24:1164–1175Google Scholar
  5. Cho DY, Leipold HW (1977) Congenital defects of the bovine central nervous system. Vet Bull 47:489–504Google Scholar
  6. Cho DY, Leipold HW (1978a) Anencephaly in calves. Cornell Vet 68:60–69Google Scholar
  7. Cho DY, Leipold HW (1978b) Agenesis of corpus callosum in calves. Cornell Vet 68:99–107Google Scholar
  8. DeMyer W, Zeman W (1963) Alobar holoprosencephaly (arhinencephaly) with median cleft lip and palate: Clinical electroencephalographic and nosologic considerations. Confin Neurol 23:1–36Google Scholar
  9. Frauchiger E, Fankhauser R (1957) Vergleichende Neuropathologie des Menschen und der Tiere. Springer, Berlin Göttingen HeidelbergGoogle Scholar
  10. Herzog A (1971) Embryonale Entwicklungsstörungen des Zentralnervensystems beim Rind. Habilitationsschrift. Institut für Erbpathologie und Zuchthygiene, Justus-Liebig-Universität, GiessenGoogle Scholar
  11. Kalter H (1968) Teratology of the central nervous system. University of Chicago Press, Chicago, pp 239–240, 313Google Scholar
  12. Yakovlev PI (1959) Pathoarchitectonic studies of cerebral malformations. III. Arhinencephalis (Holotelencephalies). J Neuropathol Exp Neurol 18:22–55Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • D. -Y. Cho
    • 1
  • D. H. Zeman
    • 1
  • J. E. Miller
    • 2
  1. 1.Dept. of Veterinary Pathology, School of Veterinary MedicineLouisiana State UniversityBaton RougeUSA
  2. 2.Dept. of Epidemiology and Community Health, School of Veterinary MedicineLouisiana State UniversityBaton RougeUSA

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