Acta Neuropathologica

, Volume 75, Issue 4, pp 377–384 | Cite as

γ-Enolase and glial fibrillary acidic protein in nervous system tumors

An immunohistochemical study using specific monoclonal antibodies
  • P. Cras
  • J. J. Martin
  • J. Gheuens
Regular Papers


A large series of central and peripheral nervous system tumors was studied for the presence of glial fibrillary acidic protein (GFAP) and γ-enolase (neuron-specific enolase, NSE), using specific monoclonal antibodies (mAbs). Occurrence in and specificity of GFAP to glial and mixed tumors was confirmed and depended on the malignancy grade and features such as meningeal invasion. Using a well-characterized mAb, γ-enolase was demonstrated in neuronal, as well as in a whole range of non-neuronal tumors. This lack of specificity of γ-enolase prohibits its use as an exclusive neuronal marker. Nevertheless quantization or comparison with other types of enolases could still prove to be useful in well-defined situations. The advantages inherent to mAbs and a highly sensitive detection system turn GFAP stainings into a specific and readily reproducible technique.

key words

Glial fibrillary acidic protein Neuron-specific enolase Monoclonal antibodies Immunocytochemistry nervous system tumors 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • P. Cras
    • 1
  • J. J. Martin
    • 1
  • J. Gheuens
    • 1
  1. 1.Laboratory of Neuropathology, Born-Bunge FoundationUniversity of AntwerpWilrijkBelgium

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