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Acta Neuropathologica

, Volume 76, Issue 3, pp 287–291 | Cite as

Marek's disease virus-induced transient paralysis in chickens: alterations in brain density

  • D. E. Swayne
  • O. J. Fletcher
  • L. W. Schierman
Regular Papers

Summary

The presence of brain edema and its distribution in Marek's disease virus(MDV)-induced transient paralysis (TP) was determined in genetically resistant and susceptible inbred White Leghorn chickens. Density measurements on samples from the cerebellum, cerebral cortex, optic chiasm, and optic lobe were determined on continuous density Percoll gradients. At 9 days post inoculation of MDV, the cerebellums from the susceptible line of chickens were significantly less dense than cerebellums from the resistant line or the controls of either line. The cerebellar edema, as measured by tissue density, coincided with the transient neurological symptoms and was not present in brain tissue from clinically recovered TP birds.

Key words

Marek's disease herpesvirus Transient paralysis Percoll Density gradients Brain edema 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • D. E. Swayne
    • 1
  • O. J. Fletcher
    • 2
  • L. W. Schierman
    • 2
  1. 1.Department of Veterinary Pathology, College of Veterinary MedicineUniversity of GeorgiaAthensUSA
  2. 2.Department of Avian Medicine; College of Veterinary MedicineUniversity of GeorgiaAthensUSA

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