Acta Neuropathologica

, Volume 78, Issue 5, pp 521–527 | Cite as

Changes in the histograms of nerves resulting from growth and various modalities of damage

A computer simulation
  • E. Bunker
  • R. L. Friede
Regular Papers


A computer program simulates the changes in a nerve's histogram during normal growth and from various neuropathies. The program shows how a nerve's histogram will change from various percentages of fiber damage or from preferential damage to either thick or thin fibers, or from various degrees of fiber restitution, or from single-event or repetitive damage. In single-event damage, the main alteration is a preponderance of thin (regenerating) fibers. Patterns of selective fiber vulnerability are difficult to deduce from the shape of the histogram. Repetitive damage remodels the histogram to a broad unimodal fiber distribution at reduced mean caliber. Comparison of simulated changes with data from an experimental isoniazid neuropathy yielded a close match between observed changes and simulation.

Key words

Computer simulation Nerve growth Neuropathy Regeneration Fiber diameter 


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Copyright information

© Springer-Verlag GmbH & Co. KG 1989

Authors and Affiliations

  • E. Bunker
    • 1
  • R. L. Friede
    • 1
  1. 1.Abteilung für NeuropathologieUniversität GöttingenGöttingenFederal Republic of Germary

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