Acta Neuropathologica

, Volume 78, Issue 5, pp 513–520 | Cite as

Intraspinal bronchogenic cyst: ultrastructural study of the lining epithelium

  • K. -L. Ho
  • R. Tiel
Regular Papers


This report describes the ultrastructural characters of the lining epithelium of a symptomatic intraspinal bronchogenic cyst at the C5-T2 level of a 21-year-old female. Six distinct cell types were recognized: ciliated cells, non-ciliated cells, and goblet cells that reached the lumen, and basal cells, Kulchitsky cells and undifferentiated cells that were basally located and did not reach the lumen. The microvilli of non-ciliated cells were coated with granulofibrillary material. Discharge of granular contents from goblet cells was noted. Abnormal cilia, particularly compound cilia, were frequent. Complex interdigitations of cytoplasmic membrane with prominent desmosomes were present in the pseudostratified region. Kulchitsky cells contained characteristic membrane-bound dense-core neurosecretory granules. Intraepithelial unmyelinated axons were observed but none were closely associated with Kulchitsky cells. The types of cells forming the lining epithelium of the present cyst and their topographic distribution within the epithelium are very similar to those of the normal tracheobronchial epithelium.

Key words

Intraspinal Bronchogenic cyst Enterogenous cyst Tracheobronchial epithelium Kulchitsky cell 


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  1. 1.
    Becci PJ, McDowell EM, Trump BF (1978) The respiratory epithelium. II. Hamster trachea, bronchus, and bronchioles. J Natl Cancer Inst 61:551–561Google Scholar
  2. 2.
    Bensch KG, Gordon GB, Miller LR (1965) Studies on the bronchial counterpart of the Kultschitsky (argentaffin) cell and innervation of bronchial glands. J Ultrastruc Res 12:668–686Google Scholar
  3. 3.
    Bentley JFR, Smith JR (1960)Developmental posterior enteric remnants and spinal malformations. The split notochord syndrome. Arch Dis Child 35:76–86Google Scholar
  4. 4.
    Breeze RG, Wheeldon EB (1977) The cells of the pulmonary airways. Am Rev Respir Dis 116:705–777Google Scholar
  5. 5.
    Dorsey JF, Tabrisky J (1966) Intraspinal and mediastinal foregut cyst compressing the spinal cord. J Neurosurg 24:562–567Google Scholar
  6. 6.
    Eraklis AJ, Griscom NT, McGovern JB (1969) Bronchogenic cysts of the mediastinum in infancy. N Engl J Med 281:1150–1155Google Scholar
  7. 7.
    Fawcett DW (1986) A textbook of histology, 11th edn. Saunders, Philadelphia, pp 735–739Google Scholar
  8. 8.
    Friede RL, Yasargil MG (1977) Supratentorial intracranial epithelial (ependymal) cysts: review, case reports and fine structure. J Neurol Neurosurg Psychiatry 40:127–137Google Scholar
  9. 9.
    Gmelich JT, Bensch KG, Liebow AA (1967) Cells of Kultschitsky type in bronchioles and their relation to the origin of peripheral carcinoid tumors. Lab Invest 17:143–160Google Scholar
  10. 10.
    Hirai O, Kawamura J, Fukumitsu T (1981) Prepontine epithelium-lined cyst. Case report. J Neurosurg 55:312–317Google Scholar
  11. 11.
    Hirano A, Ghatak, NR, Wisoff HS, Zimmerman HM (1971) An epithelial cyst of the spinal cord: an electron microscopic study. Acta Neuropathol (Berl) 18:214–223Google Scholar
  12. 12.
    Ho KL, Chason JL (1987) A glioependymal cyst of the cerebellopontine angle. Immunohistochemical and ultrastructural studies. Acta Neuropathol (Berl) 74:382–388Google Scholar
  13. 13.
    Ho KL, Chason JL (1989) Subarachnoid epithelial cyst of the cerebellum. Immunohistochemical and ultrastructural studies. Acta Neuropathol (in press)Google Scholar
  14. 14.
    Hoefnagel D, Benrischke K, Duarte J (1962) Teratomatous cysts within the vertebral canal: observations on the occurrence of sex chromatin. J Neurol Neurosurg Psychiatry 25:159–164Google Scholar
  15. 15.
    Inayama Y, Hook GER, Brody AR, Cameron GS, Jetten AM, Gilmore LB, Gray T, Nettesheim P (1988) The differentiation potential of tracheal basal cells. Lab Invest 58:706–717Google Scholar
  16. 16.
    Jeffery PK, Reid L (1973) Intraepithelial nerves in normal rat airways: a quantitative electron microscopic study. J Anat 114:35–45Google Scholar
  17. 17.
    Jeffery PK, Reid L (1975) New observations of rat airway epithelium: a quantitative and electron microscopic study. J Anat 120:295–320Google Scholar
  18. 18.
    Koto A, Horoupian DS, Shulman K (1977) Choroidal epithelial cyst. Case report. J Neurosurg 47:955–960Google Scholar
  19. 19.
    Lauweryns J, Peurkens JC (1972) Neuro-epithelial bodies (neuroreceptor or secretory organs?) in human infant bronchial and bronchiolar epithelium. Anat Rec 172:471–482Google Scholar
  20. 20.
    Leech RW, Olafson RA (1977) Epithelial cysts of the neuraxis. Presentation of three cases and a review of the origins and classification. Arch Pathol Lab Med 101:196–202Google Scholar
  21. 21.
    Maier HC (1948) Bronchiogenic cysts of the mediastinum. Ann Surg 127:476–502Google Scholar
  22. 22.
    McDowell EM, Barrett LA, Trump BF (1976) Observations on small granule cells in adult human bronchial epithelium and in carcinoid and oat cell tumors. Lab Invest 34:202–206Google Scholar
  23. 23.
    McDowell EM, Barrett LA, Glavin F (1978) The respiratory epithelium. I. Human bronchus. J Natl Cancer Inst 61:539–549Google Scholar
  24. 24.
    Rhaney K, Barclay GPT (1959) Enterogenous cysts and congenital diverticula of the alimentary canal with abnormalities of the vertebral column and spinal cord. J Pathol Bacteriol 77:457–471Google Scholar
  25. 25.
    Wilkins RH, Odom GL (1976) Spinal intradural cysts. Handb Clin Neurol 20:55–102Google Scholar
  26. 26.
    Yamashita J, Maloney AFJ, Harris P (1973) Intradural spinal bronchiogenic cyst. J Neurosurg 39:240–245Google Scholar

Copyright information

© Springer-Verlag GmbH & Co. KG 1989

Authors and Affiliations

  • K. -L. Ho
    • 1
  • R. Tiel
    • 2
  1. 1.Department of PathologyHenry Ford HospitalDetroitUSA
  2. 2.Department of NeurosurgeryHenry Ford HospitalDetroitUSA

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