Acta Neuropathologica

, Volume 12, Issue 3, pp 218–226 | Cite as

Alterations of the Z-lines and I-band myofilaments in human skeletal muscle

  • A. G. Johnson
Original Investigations


Loss of I-band myofilaments and Z-line material is described in three different pathological conditions; namely, dystrophia myotonica, sub-acute combined degeneration of the spinal cord and amyotrophic lateral sclerosis. In the case of amyotrophic lateral sclerosis hypertrophy of the Z-line is also described. A possible cyclical alteration in the Z-line in response to, so far unknown, pathological stimuli is suggested and in conjunction with this possible loss of I-band myofilaments.


Muscle Actin Z-Line Myofibril Loss of Myofilaments 


Verlust der I-Band-Myofilamente und des Materials im Z-Streifen werden bei drei verschiedenen pathologischen Zuständen beschrieben. dystrophischer Myotonie, subakuter spinaler Strangdegeneration und myatrophischer Lateralsklerose. Im Falle einer myatrophischen lateralsklerose wird auch eine Hypertrophie des Z-Streifens beschrieben. Es wird eine mögliche cyclische Alteration des Z-Streifens als Reaktion auf verschiedene, bisher unbekannte pathologische Reize und in Verbindung damit ein Verlust der Myofilamente des I-Bandes vermutet.


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Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • A. G. Johnson
    • 1
  1. 1.Midland Centre for Neurosurgery and NeurologySmethwickEngland

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