Acta Neuropathologica

, Volume 77, Issue 2, pp 136–141 | Cite as

Systemic amyloid deposition in old age and dementia of Alzheimer type: the relationship of brain amyloid to other amyloid

  • M. Yamada
  • H. Tsukagoshi
  • E. Otomo
  • M. Hayakawa
Regular Papers


We investigated amyloid deposition in the brain and other organs in 105 consecutive autopsy cases, aged 59 to 101 years. They consisted of two groups; 15 patients with dementia of Alzheimer type (DAT) and 90 patients without DAT. Amyloid deposition was found in 93% of all cases. The incidence of amyloid deposition increased with age. The number of organs affected with amyloid deposition in each case also increased with age. The incidence of amyloid deposition in each organ was as follows; 88% in pituitary gland, 66% in brain [amyloid of senile plaque (SP) (61%) and/or cerebral amyloid angiopathy (CAA) (56%)], 33% in pancreas, 3% in heart, and less in others. In immunohistochemical studies using the antisera to the various kinds of amyloid or related proteins, amyloid β protein was demonstrated in brain amyloids including SP and CAA, but not in others. Cardiac amyloid was positive for prealbumin. Pituitary amyloid and CAA were positive for amyloid P-component. The incidence of brain amyloids in DAT were significantly higher than that in non-DAT. There was no significant difference in the incidence of pituitary and pancreatic amyloid between DAT and non-DAT. In the non-DAT patients, there were significant positive correlations in amyloid deposition between the brain and pituitary gland and between the brain and pancreas. Acceleration of amyloid deposition would be a process confined to the brain in the patients with DAT. The pathogenesis of the accelerated deposition of brain amyloids is discussed from the point of view of amyloidosis.

Key words

Amyloid deposition Amyloid protein Ageing Dementia of Alzheimer type 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • M. Yamada
    • 1
  • H. Tsukagoshi
    • 1
  • E. Otomo
    • 2
  • M. Hayakawa
    • 3
  1. 1.Department of Neurology, Faculty of MedicineTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of Internal MedicineYokufukai Geriatric HospitalTokyoJapan
  3. 3.Department of PathologyYokufukai Geriatric HospitalTokyoJapan

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